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A survey to investigate resistance to drugs used in the treatment of bovine trypanosomosis was conducted in the eastern province of Zambia between 1996 and 1998. A cross-sectional study was conducted in three districts (Petauke, Katete, Lundazi) at 34 village sampling sites selected at random fr...


Sinyangwe, L.Delespaux, V.Brandt, J.Geerts, S.Mubanga, J.Machila, N.Holmes, P.H.Eisler, M.C.[Trypanocidal drug resistance in eastern province of Zambia]Trypanocidal drug resistance in eastern province of Zambia

A study using a structured questionnaire was conducted in Busia District, Western Kenya and Kwale District, Coastal Kenya to obtain qualitative and quantitative information from 256 cattle owners about their production systems, their perceptions of the diseases encountered in their cattle, the ...


Machila, N.Wanyangu, S.W.McDermott, John J.Welburn, S.C.Maudlin, I.Eisler, M.C.[Cattle owners' perceptions of African bovine trypanosomiasis and its control in Busia and Kwale Districts of Kenya]Cattle owners' perceptions of African bovine trypanosomiasis and its control in Busia and Kwale Districts of Kenya

This paper describes the development, design, dissemination and evaluation of a communication intervention designed to promote appropriate usage of trypanocidal drugs in trypanosomiasis endemic areas of western and coastal Kenya. Following a baseline study on current trypanosomiasis knowledge, at...


Machila, N.Emongor, RosemaryShaw, A.P.Welburn, S.C.McDermott, John J.Maudlin, I.Eisler, M.C.[A community education intervention to improve bovine trypanosomiasis knowledge and appropriate use of trypanocidal drugs on smallholder farms in Kenya]A community education intervention to improve bovine trypanosomiasis knowledge and appropriate use of trypanocidal drugs on smallholder farms in Kenya

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...


Eisler, M.C.Brandt, J.Bauer, B.Clausen, P.H.Delespaux, V.Holmes, P.H.Ilemobade, A.Machila, N.Mbwambo, H.McDermott, John J.Mehlitz, D.Murilla, G.Ndung'u, J.M.Peregrine, A.S.Sidibe, I.Sinyangwe, L.Geerts, S.[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle

The indirect enzyme-linked immunosorbent assay (ELISA) for the detection of anti-trypanosomal antibodies in bovine serum was adapted for use with dried blood spots on filter paper. Aborbance (450 nm) results for samples were expressed as percent positivity, i.e., percentage of the median absorban...


Hopkins, J.S.Chitambo, H.Machila, N.Luckins, A.G.Rae, P.F.Bossche, P. van denEisler, M.C.[Adaptation and validation of antibody-ELISA using dried blood spots on filter paper for epidemiological surveys of tsetse-transmitted trypanosomosis in cattle]Adaptation and validation of antibody-ELISA using dried blood spots on filter paper for epidemiological surveys of tsetse-transmitted trypanosomosis in cattle

Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...


Eisler, M.C.McDermott, John J.Mdachi, R.Murilla, G.Sinyangwe, L.Mubanga, J.Machila, N.Mbwambo, H.Coleman, P.G.Clausen, P.H.Bauer, B.Sidibe, I.Geerts, S.Holmes, P.H.Peregrine, A.S.[Rapid method for the assessment of trypanocidal drug resistance in the field]Rapid method for the assessment of trypanocidal drug resistance in the field

Bovine trypanosomiasis caused by pathogenic trypanosomes, and cyclically transmitted by tsetse flies, is considered to be a major disease constraint to livestock production in sub-Saharan Africa, preventing full use of the land to feed the rapidly increasing human population. Privatisation of vet...


Machila, N.Eisler, M.C.Wanyangu, S.W.McDermott, John J.Welburn, S.C.Maudlin, I.[Cattle owners' perceptions of African bovine trypanosomiasis and its control in Busia and Kwale districts of Kenya]Cattle owners' perceptions of African bovine trypanosomiasis and its control in Busia and Kwale districts of Kenya

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