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The authors highlight the reliance on repeated natural infections by tickborne pathogens to maintain immunity in immunized herds. That incidence of clinical heartwater in cattle, caused by Cowdria ruminantium, is low while intensive acaricide use interrupts transmission of pathogens. Evidence is ...


Perry, Brian D.Chamboko, TafireyiMahan, S.M.Medley, G.F.Minjauw, B.O'Callaghan, C.J.Peter, T.F.[The economics of integrated tick and tick-borne disease control on commercial farms in Zimbabwe]The economics of integrated tick and tick-borne disease control on commercial farms in Zimbabwe

Analysis of the transmission dynamics of Cowdria ruminantium, the tick-borne rickettsial agent of heartwater in ruminants, requires accurate measures of infection in vector populations. To obtain these, Amblyomma hebraeum ticks were collected at two heartwater-endemic locations in the lowveld and...


Peter, T.F.Perry, Brian D.O'Callaghan, C.J.Medley, G.F.Mlambo, G.Barbet, A.F.Mahan, S.M.[Prevalence of Cowdria ruminantium infection in Amblyomma hebraeum ticks from heartwater-endemic areas of Zimbabwe]Prevalence of Cowdria ruminantium infection in Amblyomma hebraeum ticks from heartwater-endemic areas of Zimbabwe

In order to assess the economic impact of heartwater (Cowdria ruminantium infection) and model the impact of improved vaccines against the disease, a field study was conducted to provide data on livestock productivity indicators in Zimbabwe. Cross-sectional studies were performed in the two main ...


Chamboko, TafireyiMukhebi, A.W.O'Callaghan, C.J.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[Heartwater and the economics of livestock production on large scale commercial and smallholder farms in Zimbabwe]Heartwater and the economics of livestock production on large scale commercial and smallholder farms in Zimbabwe

The tick vectors of heartwater (Cowdria ruminantium infection) in Zimbabwe, Amblyomma hebraeum and Amblyomma variegatum, historically were believed to be confined to the low-lying regions of the south and north-west of the country. However, country-wide surveys performed in 1975-1980 and 1988-199...


Peter, T.F.Perry, Brian D.O'Callaghan, C.J.Medley, G.F.Shumba, W.Madzima, W.Burridge, M.J.Mahan, S.M.[Distributions of the vectors of heartwater, Amblyomma hebraeum and amblyomma variegatum (Acari: Ixodidae), in Zimbabwe]Distributions of the vectors of heartwater, Amblyomma hebraeum and amblyomma variegatum (Acari: Ixodidae), in Zimbabwe

Heartwater is a disease of high mortality in domestic ruminants (cattle, sheep and goats) in sub-Saharan Africa and in the Caribbean. An intracellular rickettsia, Cowdria ruminantium, is the cause of the disease and is transmitted by ticks of the genus Amblyomma. Losses due to heartwater are high...


Peter, T.F.O'Callaghan, C.J.Medley, G.F.Mahan, S.M.Perry, Brian D.[Biological support for modeling the transmission dynamics of cowdriosis]Biological support for modeling the transmission dynamics of cowdriosis

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...


Totte, P.McKeever, Declan J.Jongejan, F.Barbet, A.Mahan, S.M.Mwangi, D.Bensaid, A.[Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium]Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium

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