There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...
Mwangi, D.M.
,
McKeever, Declan J.
,
Nyanjui, J.K.
,
Barbet, A.F.
,
Mahan, S.M.
,
[Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent]
,
Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Peripheral blood mononuclear cells (PBMC) from immune cattle proliferate in the presence of autologous Cowdria ruminantium-infected endothelial cells and monocytes. Endothelial cells required treatment with T-cell growth factors to induce class II major histocompatibility complex expression prior...
Mwangi, D.M.
,
Mahan, S.M.
,
Nyanjui, J.K.
,
Taracha, E.L.N.
,
McKeever, Declan J.
,
[Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes]
,
Immunization of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes
The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...
Totte, P.
,
McKeever, Declan J.
,
Jongejan, F.
,
Barbet, A.
,
Mahan, S.M.
,
Mwangi, D.
,
Bensaid, A.
,
[Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium]
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Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium