There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...
Mwangi, D.M.
,
McKeever, Declan J.
,
Nyanjui, J.K.
,
Barbet, A.F.
,
Mahan, S.M.
,
[Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent]
,
Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Understanding the basis of protective immunity to Cowdria ruminantium will facilitate the development of an effective subunit vaccine against heartwater in ruminants and contribute to a better definition of protective immune mechanisms to obligate intracellular pathogens in general. Until recentl...
Totte, P.
,
Bensaid, A.
,
Mahan, S.M.
,
Martínez, D.
,
McKeever, Declan J.
,
[Immune responses to Cowdria ruminantium infections]
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Immune responses to Cowdria ruminantium infections
The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...
Totte, P.
,
McKeever, Declan J.
,
Jongejan, F.
,
Barbet, A.
,
Mahan, S.M.
,
Mwangi, D.
,
Bensaid, A.
,
[Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium]
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Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium
Heartwater (cowdriosis) is an infectious disease of domestic ruminants in Africa and the Carribean and is caused by a tick-borne intracellular rickettsial agent, Cowdria ruminantium. There is growing evidence that immunity of cattle to the disease is medicated by T. lymphocytes. Antigens that sti...
Mwangi, D.M.
,
McKeever, Declan J.
,
Nyanjui, J.K.
,
Barbet, A.F.
,
Mahan, S.M.
,
[Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle]
,
Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle