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Previous molecular genetic studies on the African trypanosome have focused on only a few genes and gene products, the majority of which are concerned with surface antigenic variation: consequently, an insignificant number of the genes of this organism have been characterized to date. In order to:...


Djikeng, AppolinaireAgufa, C.Donelson, J.E.Majiwa, P.A.O.[Generation of expressed sequence tags as physical landmarks in the genome of Trypanosoma brucei]Generation of expressed sequence tags as physical landmarks in the genome of Trypanosoma brucei

During its first two years, the African trypanosome genome project, funded in part by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), has concentrated on three fundamental areas: (1) gene discovery by single-pass sequencing of cDNAs to produce expre...


Melville, S.E.Majiwa, P.A.O.Donelson, J.E.[Resources available from the African Trypanosome Genome Project]Resources available from the African Trypanosome Genome Project

The pathogenic trypanosomes Trypanosoma vivax and Trypanosoma congolense are transmitted by tsetse and cause trypanosomosis, a debilitating disease affecting livestock in Africa and South America. Here, we discuss the need, relevance and advantage of having the Trypanosoma genomes sequenced, an...


Davila, A.M.R.Majiwa, P.A.O.Grisard, E.C.Aksoy, S.Melville, S.E.[Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes]Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes
Williams, R.O.Young, J.R.Majiwa, P.A.O.[Genomic rearrangements correlated with antigenic variation in Trypanosoma brucei]Genomic rearrangements correlated with antigenic variation in Trypanosoma brucei

There have been tremendous advances in our knowledge of trypanosome biology, yet many aspects remain unclear. Currently, the genome of Trypanosome brucei is being sequenced and this, with other genome-wide analysis methods, could provide novel insights into the parasite and facilitate the develop...


Agbo, E.C.Majiwa, P.A.O.Bascher, P.Claassen, E.Marinus, F.W.P.[Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets]Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets

The recent genome initiatives of the neglected parasites Trypanosoma vivax and Trypanosoma congolense, and the vector tsetse are promising with regards to the data available in public databases. While these genome initiatives and the potential for developing new drugs and vaccines are admirable, ...


Davila, A.M.R.Majiwa, P.A.O.Grisard, E.C.Aksoy, S.Hide, W.[Response to Hertz-Fowler and Berriman: Continuing tsetse and trypanosoma genome sequencing projects]Response to Hertz-Fowler and Berriman: Continuing tsetse and trypanosoma genome sequencing projects

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