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Kaminsky, R.Mamman, M.Chuma, FrancisZweygarth, E.[Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenir) and in vitro simulation of drug-concentration-time profiles in cattle plasma]Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenir) and in vitro simulation of drug-concentration-time profiles in cattle plasma

Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...


Mamman, M.Williams, D.J.L.Murphy, N.B.Peregrine, A.S.[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
Mamman, M.Katende, J.Moloo, S.K.Peregrine, A.S.[Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats]Variation in sensitivity of Trypanosoma congolense to diminazene during the early phase of tsetse-transmitted infection in goats

The frequency of trypanosomes resistant to diminazene aceturate at a dose of 26 mg/kg of bwt was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene aceturate at the same dosage. At inoculum sizes of 102,...


Mamman, M.Gettinby, N.B.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate]Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate

Diminazene aceturate is one of a limited number of drugs currently being used in animals to treat the tsetse fly-transmitted protozoal disease, African trypanosomiasis. Efficacy of the drug at the recommended single IM administered doses of 3.5 and 7.0 mg/kg of body weight is widely acknowledged....


Mamman, M.McKeever, Declan J.Aliu, Y.O.Peregrine, A.S.[Pharmacokinetics of diminazene in plasma and lymph of goats]Pharmacokinetics of diminazene in plasma and lymph of goats
Peregrine, A.S.Mamman, M.[A simple method for repeated sampling of lumbar cerebrospinal fluid in goats]A simple method for repeated sampling of lumbar cerebrospinal fluid in goats
Mamman, M.Gettinby, G.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene]Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene

Peregrine, A.S.Sutherland, I.A.Mutharia, L.Jamnadass, Ramni H.Gray, M.A.Codjia, V.Aliu, Y.O.Mamman, M.Silayo, R.D'Ieteren, G.D.M.Moloo, S.K.Murphy, N.B.[Overview of the chemotherapy research program at ILRAD]Overview of the chemotherapy research program at ILRAD

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