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The current control strategies for tsetse-transmitted trypanosomosis in cattle (trypanocidal drugs tsetse control and trypanotolerant cattle) are briefly reviewed and their adoption rates in different geographic regions of sub-Saharan Africa are presented. The impact of these control strategies a...


McDermott, John J.Coleman, P.G.[Comparing apples and oranges - model-based assessment of different tsetse-transmitted trypanosomosis control strategies]Comparing apples and oranges - model-based assessment of different tsetse-transmitted trypanosomosis control strategies

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...


Eisler, M.C.Brandt, J.Bauer, B.Clausen, P.H.Delespaux, V.Holmes, P.H.Ilemobade, A.Machila, N.Mbwambo, H.McDermott, John J.Mehlitz, D.Murilla, G.Ndung'u, J.M.Peregrine, A.S.Sidibe, I.Sinyangwe, L.Geerts, S.[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle

Tsetse-transmitted trypanosomosis affects cattle production over approximately 10 million km2 of Africa. In these areas, trypanocidal drugs, both prophylactic and curative, are the most widely used methods of trypanosomosis control. However, resistance of trypanosomes to the 3 trypanocidal drugs ...


McDermott, John J.Coleman, P.G.Eisler, M.C.Peregrine, A.S.[The effects of resistance to trypanocidal drugs on trypanosome transmission]The effects of resistance to trypanocidal drugs on trypanosome transmission

The identification and tracking of sub-populations through time and space are critical to fully understanding the epidemiology of parasitic diseases. However, very little is known about the structure, distribution and dynamics of trypanosome populations in the field. Most laboratory studies that ...


Coleman, P.G.McDermott, John J.[Trypanosome population biology - an approach to support the control of drug resistance and integrated trypanosomosis control]Trypanosome population biology - an approach to support the control of drug resistance and integrated trypanosomosis control

The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance...


Eisler, M.C.Ndung'u, J.M.Murilla, G.Mdachi, R.M.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Geerts, S.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.[Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa]Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa

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