Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...
Eisler, M.C.
,
Brandt, J.
,
Bauer, B.
,
Clausen, P.H.
,
Delespaux, V.
,
Holmes, P.H.
,
Ilemobade, A.
,
Machila, N.
,
Mbwambo, H.
,
McDermott, John J.
,
Mehlitz, D.
,
Murilla, G.
,
Ndung'u, J.M.
,
Peregrine, A.S.
,
Sidibe, I.
,
Sinyangwe, L.
,
Geerts, S.
,
[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]
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Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle
The aim of this study was to assess, whether polymerase chain reaction (PCR) allows sensitive screening of treatment failure suspicions in areas, where drug resistance against African animal trypanosomosis (AAT) appears to be a problem. PCR was used to detect trypanosome infections prior to, 14 ...
Gall, Y.
,
Woitag, T.
,
Bauer, B.
,
Sidibe, I.
,
McDermott, John J.
,
Mehlitz, D.
,
Clausen, P.H.
,
[Trypanocidal failure suggested by PCR results in cattle field samples]
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Trypanocidal failure suggested by PCR results in cattle field samples
Drug resistant trypanosome infections in livestock have been Reported from 13 sub-Saharan countries so far, in eight of which multiple resistance occurs. Since new trypanocides are unlikely to appear on the market in the near future, information about the occurrence, extent and impact of drug res...
Gall, Y.
,
Woitag, J.
,
Bauer, B.
,
Sidibe, I.
,
McDermott, John J.
,
Eisler, M.C.
,
Mehlitz, D.
,
Clausen, P.H.
,
[Detection of trypanocide failure in cattle: Diagnostic potential of PCR compared to parasitological methods]
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Detection of trypanocide failure in cattle: Diagnostic potential of PCR compared to parasitological methods
Currently in Southeast Uganda, FITCA (EU funded Farming in Tsetse Controlled Areas Project) is involved in an intervention programme against both animal trypanosomiasis and human sleeping sickness. This is a regional project involving Kenya, Ethiopia, Tanzania and Uganda. In southeast Uganda, the...
Fyfe. K.
,
Picozzi, K.
,
Fèvre, Eric M.
,
Wasiwa, C.
,
McDermott, John J.
,
Welburn, S.C.
,
[Assessment of trypanosome prevalence in FITCA high risk areas]
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Assessment of trypanosome prevalence in FITCA high risk areas
A one-year longitudinal study was conducted in 92 smallholder diary farms in Kwale district of Kenya, to evaluate the efficacy of Spot-on® (a 10% deltamethrin pour-on) in the control of East Coast fever, anaplasmosis, babesiosis and trypanosomosis. A comparison of the annual incidence and mortali...
Muraguri, G.R.
,
McLeod, A.
,
McDermott, John J.
,
[Efficacy of a deltamethrin-based pour-on in the control of tick-borne diseases and trypanosomosis in Kwale District, Kenya]
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Efficacy of a deltamethrin-based pour-on in the control of tick-borne diseases and trypanosomosis in Kwale District, Kenya
Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...
Eisler, M.C.
,
McDermott, John J.
,
Mdachi, R.
,
Murilla, G.
,
Sinyangwe, L.
,
Mubanga, J.
,
Machila, N.
,
Mbwambo, H.
,
Coleman, P.G.
,
Clausen, P.H.
,
Bauer, B.
,
Sidibe, I.
,
Geerts, S.
,
Holmes, P.H.
,
Peregrine, A.S.
,
[Rapid method for the assessment of trypanocidal drug resistance in the field]
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Rapid method for the assessment of trypanocidal drug resistance in the field
McDermott, John J.
,
Coleman, P.G.
,
[Research into trypanosomosis epidemiology: The Essential contributions of theory, models and diagnostics]
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Research into trypanosomosis epidemiology: The Essential contributions of theory, models and diagnostics
Coleman, P.G.
,
McDermott, John J.
,
Maudlin, I.
,
[The public health impact of controlling Trypanosoma brucei rhodesiense in cattle]
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The public health impact of controlling Trypanosoma brucei rhodesiense in cattle
The identification and tracking of sub-populations through time and space are critical to fully understanding the epidemiology of parasitic diseases. However, very little is known about the structure, distribution and dynamics of trypanosome populations in the field. Most laboratory studies that ...
Coleman, P.G.
,
McDermott, John J.
,
[Trypanosome population biology - an approach to support the control of drug resistance and integrated trypanosomosis control]
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Trypanosome population biology - an approach to support the control of drug resistance and integrated trypanosomosis control