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The main aim of this meeting was to review those developments in the fields of immunology and immunoparasitology that have relevance to the development of vaccination strategies for ECF and trypanosomiasis. Of relevance to the control of ECF were recent developments in the elucidation of events t...
Theileria parva is the causal agent of East Coast fever (ECF), a fatal disease of cattle characterized by pyrexia, transient lymphadenopathy and panleukopenia. We have evaluated monoclonal antibodies (mAb) against three distinct antigens (p67, PIM and p32) of the parasite as immunohistological re...
Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...
Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an i...
The Development of a recombinant Theileria parva vaccine is discussed under the following headings: mechanisms of protection against ECF [East Coast fever]; cloning and expression of p67; immunization and challenge of cattle; interpretation of immunization and challenge data.
Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...
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