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The main aim of this meeting was to review those developments in the fields of immunology and immunoparasitology that have relevance to the development of vaccination strategies for ECF and trypanosomiasis. Of relevance to the control of ECF were recent developments in the elucidation of events t...


McKeever, Declan J.[Novel immunization strategies against protozoan parasites. Proceedings of a workshop]Novel immunization strategies against protozoan parasites. Proceedings of a workshop

Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...


McKeever, Declan J.Taracha, E.L.N.Morrison, W. IvanMusoke, A.J.Morzaria, S.P.[Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies]Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies

Understanding the basis of protective immunity to Cowdria ruminantium will facilitate the development of an effective subunit vaccine against heartwater in ruminants and contribute to a better definition of protective immune mechanisms to obligate intracellular pathogens in general. Until recentl...


Totte, P.Bensaid, A.Mahan, S.M.Martínez, D.McKeever, Declan J.[Immune responses to Cowdria ruminantium infections]Immune responses to Cowdria ruminantium infections
McKeever, Declan J.Morrison, W. Ivan[Theileria parva: The nature of the immune response and its significance for immunoprophylaxis]Theileria parva: The nature of the immune response and its significance for immunoprophylaxis
McKeever, Declan J.Awino, J.Morrison, W. Ivan[Afferent lymph veiled cells prime CD4+ T cell responses in vivo]Afferent lymph veiled cells prime CD4+ T cell responses in vivo

Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...


Totte, P.McKeever, Declan J.Jongejan, F.Barbet, A.Mahan, S.M.Mwangi, D.Bensaid, A.[Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium]Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium

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