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Journal Article 1997

Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium

Autor: Totte, P. McKeever, Declan J. Martínez, D. Bensaid, A.

Cattle were successfully immunized against heartwater with a lysate of Cowdria ruminantium formulated in Freund's adjuvant. Vaccinated animals proved fully resistant to virulent challenge 3 and 10 months after vaccination. For the first time a helper T lymphocyte response to Cowdria antigens was ...

Enlace original: https://cgspace.cgiar.org/handle/10568/28765

Investigación en Agricultura

COWDRIA RUMINANTIUM

CATTLE

IMMUNIZATION

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Totte, P. , McKeever, Declan J. , Martínez, D. , Bensaid, A. , [Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium] , Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium

Journal Article 1991

Bovine afferent lymph veiled cells differ from blood monocytes in phenotype and accessory function

Autor: McKeever, Declan J. MacHugh, Niall D. Goddeeris, B.M. Awino, Elias Morrison, W. Ivan

Enlace original: https://cgspace.cgiar.org/handle/10568/28917

Investigación en Agricultura

CATTLE

ANIMAL DISEASES

LYMPHOCYTES

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McKeever, Declan J. , MacHugh, Niall D. , Goddeeris, B.M. , Awino, Elias , Morrison, W. Ivan , [Bovine afferent lymph veiled cells differ from blood monocytes in phenotype and accessory function] , Bovine afferent lymph veiled cells differ from blood monocytes in phenotype and accessory function

Journal Article 1993

A monoclonal antibody specific for bovine CD45RO differentiates memory from naive CD4 positive bovine T-cells

Autor: MacHugh, Niall D. Awino, Elias McKeever, Declan J.

Enlace original: https://cgspace.cgiar.org/handle/10568/29864

Investigación en Agricultura

CATTLE

MONOCLONAL ANTIBODIES

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MacHugh, Niall D. , Awino, Elias , McKeever, Declan J. , [A monoclonal antibody specific for bovine CD45RO differentiates memory from naive CD4 positive bovine T-cells] , A monoclonal antibody specific for bovine CD45RO differentiates memory from naive CD4 positive bovine T-cells

Journal Article 1998

Identification of diverse BoLA DQA3 genes consistent with non-allelic sequences

Autor: Ballingall, K.T. Marasa, B.S. Luyai, A. McKeever, Declan J.

Previous analysis of the second exon sequences derived from genomic DQA3 genes of the MHC in cattle identified 2 distinct families, DQA3*01 and DQA3*02. In this paper, the nucleotide and predicted amino acid sequences of the entire coding region of 3 transcribed DQA3 genes representing each of th...

Enlace original: https://cgspace.cgiar.org/handle/10568/30063

Investigación en Agricultura

MAJOR HISTOCOMPATIBILITY COMPLEX

NUCLEOTIDE SEQUENCES

CATTLE

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Ballingall, K.T. , Marasa, B.S. , Luyai, A. , McKeever, Declan J. , [Identification of diverse BoLA DQA3 genes consistent with non-allelic sequences] , Identification of diverse BoLA DQA3 genes consistent with non-allelic sequences

Book Chapter 1994

A recombinant vaccine for Theileria parva

Autor: Musoke, A.J. McKeever, Declan J. Morzaria, S.P. Nkonge, C. Nene, Vishvanath

The Development of a recombinant Theileria parva vaccine is discussed under the following headings: mechanisms of protection against ECF [East Coast fever]; cloning and expression of p67; immunization and challenge of cattle; interpretation of immunization and challenge data.

Enlace original: https://cgspace.cgiar.org/handle/10568/50104

Investigación en Agricultura

EAST COAST FEVER

THEILERIA PARVA

CATTLE

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Musoke, A.J. , McKeever, Declan J. , Morzaria, S.P. , Nkonge, C. , Nene, Vishvanath , [A recombinant vaccine for Theileria parva] , A recombinant vaccine for Theileria parva

Journal Article 1998

Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium

Autor: Totte, P. McKeever, Declan J. Jongejan, F. Barbet, A. Mahan, S.M. Mwangi, D. Bensaid, A.

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...

Enlace original: https://cgspace.cgiar.org/handle/10568/33077

Investigación en Agricultura

CATTLE

RUMINANTS

COWDRIA RUMINANTIUM

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Totte, P. , McKeever, Declan J. , Jongejan, F. , Barbet, A. , Mahan, S.M. , Mwangi, D. , Bensaid, A. , [Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium] , Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium

Journal Article 1998

Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle

Autor: Mwangi, D.M. McKeever, Declan J. Nyanjui, J.K. Barbet, A.F. Mahan, S.M.

Heartwater (cowdriosis) is an infectious disease of domestic ruminants in Africa and the Carribean and is caused by a tick-borne intracellular rickettsial agent, Cowdria ruminantium. There is growing evidence that immunity of cattle to the disease is medicated by T. lymphocytes. Antigens that sti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33078

Investigación en Agricultura

COWDRIA RUMINANTIUM

CATTLE

LYMPHOCYTE

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Mwangi, D.M. , McKeever, Declan J. , Nyanjui, J.K. , Barbet, A.F. , Mahan, S.M. , [Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle] , Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle

Conference Paper 1995

Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes

Autor: Taracha, E.L.N. McKeever, Declan J.

This paper determines whether contact between parasite-specific CD4+ T cells and CD8+ T cells is an essential requirement for helper function, additional experiments were performed using two-chamber culture plates incorporating semi-porous membranes. TpM were co-cultured with naive or immune CD8 ...

Enlace original: https://cgspace.cgiar.org/handle/10568/3131

Investigación en Agricultura

THEILERIA PARVA

ANIMAL DISEASES

METASTIGMATA

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Taracha, E.L.N. , McKeever, Declan J. , [Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes] , Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes

Journal Article 2013-10-17

Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge

Autor: Mulongo, M.M. Frey, J. Smith, K. Schnier, C. Wesonga, H.O. Naessens, Jan McKeever, Declan J.

The membrane-associated enzyme l-α-glycerol-3-phosphate oxidase (GlpO) of Mycoplasma mycoides subs. mycoides (Mmm), the causal agent of contagious bovine pleuropneumonia (CBPP) has been identified as a virulence factor responsible for the release of toxic by-products such as H2O2 that mediate hos...

Enlace original: https://cgspace.cgiar.org/handle/10568/33803

Investigación en Agricultura

VACCINES

CATTLE

ANIMAL DISEASES

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Mulongo, M.M. , Frey, J. , Smith, K. , Schnier, C. , Wesonga, H.O. , Naessens, Jan , McKeever, Declan J. , [Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge] , Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge

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