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McKeever, Declan J.[The role of class I MHC-restricted cytotoxic T cells in protection on immune cattle from Theileria parva]The role of class I MHC-restricted cytotoxic T cells in protection on immune cattle from Theileria parva

Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite
McKeever, Declan J.[Progress towards a vaccine against Theileria parva: Relevance for heartwater research]Progress towards a vaccine against Theileria parva: Relevance for heartwater research

Theileria parva, an obligate intracellular protozoan parasite of cattle, causes East Coast fever, a fatal, lymphoproliferative disease, endemic in large areas of East and Central Africa. The mammalian-infective sporozoites of T. parva mature within the salivary glands of the ixodid tick Rhipiceph...


Wells, C.W.Awino, EliasMcKeever, Declan J.[Theileria parva sporozoite invasion and development within bovine dendritic cells]Theileria parva sporozoite invasion and development within bovine dendritic cells

The Development of a recombinant Theileria parva vaccine is discussed under the following headings: mechanisms of protection against ECF [East Coast fever]; cloning and expression of p67; immunization and challenge of cattle; interpretation of immunization and challenge data.


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[A recombinant vaccine for Theileria parva]A recombinant vaccine for Theileria parva
Nene, VishvanathBishop, Richard P.Dolan, T.T.McKeever, Declan J.Ole-MoiYoi, O.K.Morzaria, S.P.Musoke, A.J.Shaw, M.K.Toye, Philip G.Young, A.S.[Theileria parva: current status]Theileria parva: current status
McKeever, Declan J.Taracha, E.L.N.Innes, E.L.MacHugh, Niall D.Awino, EliasGoddeeris, B.M.Morrison, W. Ivan[Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph]Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph

This paper determines whether contact between parasite-specific CD4+ T cells and CD8+ T cells is an essential requirement for helper function, additional experiments were performed using two-chamber culture plates incorporating semi-porous membranes. TpM were co-cultured with naive or immune CD8 ...


Taracha, E.L.N.McKeever, Declan J.[Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes]Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes

Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen

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