A live, attenuated vaccine is currently the only viable option to control of CBPP in Africa. It has been suggested that simple modifications to current vaccines and protocols might improve efficacy in the field. In this report we compared the current vaccine formulation with a buffered preparatio...
Nkando, I.
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Ndinda, J.
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Kuria, J.
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Naessens, Jan
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Mbithi, F.
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Schnier, C.
,
Gicheru, M.
,
McKeever, Declan J.
,
Wesonga, H.O.
,
[Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle]
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Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle
Previous data showed that six out of a group of nine cattle inoculated with NS1-p67, a recombinant form of a 67-KDa Theileria parva sporozoite surface protein, were immune to East Coast fever. This bacterialy expressed antigen encoded all 709 amino acid residues of p67 fused to the C-terminal end...
Nene, Vishvanath
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Inumaru, S.
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McKeever, Declan J.
,
Morzaria, S.P.
,
Shaw, M.
,
Musoke, A.J.
,
[Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle]
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Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle
Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an i...
Ballingall, K.T.
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Luyai, A.
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Rowlands, G.J.
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Sales, J.
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Musoke, A.J.
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Morzaria, S.P.
,
McKeever, Declan J.
,
[Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen]
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Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen
We evaluated sexual recombination in the apicomplexan parasite Theileria parva using genome-wide marker analysis of haploid sporozoite populations obtained from infected Rhipicephalus appendiculatus ticks. Analysis of 231 parasite clones derived by in vitro infection of bovine lymphocytes reveale...
Katzer, F.
,
Ngugi, D.
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Oura, C.
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Bishop, Richard P.
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Taracha, E.L.N.
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Walker, A.R.
,
McKeever, Declan J.
,
[Extensive genotypic diversity in a recombining population of the apicomplexan parasite Theileria parva]
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Extensive genotypic diversity in a recombining population of the apicomplexan parasite Theileria parva
Development of improved vaccine and diagnostic-based disease control strategies has benefited considerably from advances in biotechnology, particularly those relating to recombinant DNA technology. Efficiency of the vaccine development process has been increased at all levels, from the analysis o...
McKeever, Declan J.
,
Rege, J.E.O.
,
[Vaccines and diagnostic tools for animal health: The influence of biotechnology]
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Vaccines and diagnostic tools for animal health: The influence of biotechnology
Howard, C.J.
,
Sopp, P.
,
Parsons, K.R.
,
McKeever, Declan J.
,
Taracha, E.L.N.
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Jones, B.V.
,
MacHugh, Niall D.
,
Morrison, W. Ivan
,
[Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45]
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Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45
Musoke, A.J.
,
Nene, Vishvanath
,
McKeever, Declan J.
,
[Epitope specificity of bovine immune responses to the major surface antigen of Theileria parva sporozoites]
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Epitope specificity of bovine immune responses to the major surface antigen of Theileria parva sporozoites
Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...
Musoke, A.J.
,
McKeever, Declan J.
,
Morzaria, S.P.
,
Nkonge, C.
,
Nene, Vishvanath
,
[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]
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Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen