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Nene, VishvanathBishop, Richard P.Dolan, T.T.McKeever, Declan J.Ole-MoiYoi, O.K.Morzaria, S.P.Musoke, A.J.Shaw, M.K.Toye, Philip G.Young, A.S.[Theileria parva: current status]Theileria parva: current status

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...


Totte, P.McKeever, Declan J.Jongejan, F.Barbet, A.Mahan, S.M.Mwangi, D.Bensaid, A.[Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium]Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium

Heartwater (cowdriosis) is an infectious disease of domestic ruminants in Africa and the Carribean and is caused by a tick-borne intracellular rickettsial agent, Cowdria ruminantium. There is growing evidence that immunity of cattle to the disease is medicated by T. lymphocytes. Antigens that sti...


Mwangi, D.M.McKeever, Declan J.Nyanjui, J.K.Barbet, A.F.Mahan, S.M.[Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle]Major antigenic proteins 1 and 2 of Cowdria ruminantium are targets for T-lymphocyte responses of immune cattle
McKeever, Declan J.Taracha, E.L.N.Innes, E.L.MacHugh, Niall D.Awino, EliasGoddeeris, B.M.Morrison, W. Ivan[Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph]Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph

This paper determines whether contact between parasite-specific CD4+ T cells and CD8+ T cells is an essential requirement for helper function, additional experiments were performed using two-chamber culture plates incorporating semi-porous membranes. TpM were co-cultured with naive or immune CD8 ...


Taracha, E.L.N.McKeever, Declan J.[Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes]Inductive requirements of Theileria parva-specific cytotoxic T lymphocytes

Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen

The objective of this study was to synthesise the best available scientific knowledge about zoonotic disease transmission through livestock and wildlife interaction (direct or indirect), with emphasis on risk factors, drivers and trajectories of transmission, as well as promising interventions fo...


Jones, B.McKeever, Declan J.Grace, DeliaPfeiffer, Dirk U.Mutua, F.Njuki, JemimahMcDermott, John J.Rushton, JonathanSaid, Mohammed YahyaEricksen, Polly J.Kock, R.Alonso, Silvia[Zoonoses (Project 1): Wildlife/domestic livestock interactions]Zoonoses (Project 1): Wildlife/domestic livestock interactions

Abstract Contagious bovine pleuropneumonia (CBPP) is an economically important disease in most of sub-Saharan Africa. A conjoint analysis and ordered probit regression models were used to measure the preferences of farmers for CBPP vaccine and vaccination attributes. This was with regard to inclu...


Kairu-Wanyoike, S.W.Kaitibie, S.Taylor, N.M.Gitau, G.K.Heffernan, C.L.Schnier, C.Kiara, Henry K.Taracha, E.A.McKeever, Declan J.[Exploring farmer preferences for contagious pleuropneumonia vaccination: A case study in Narok district of Kenya]Exploring farmer preferences for contagious pleuropneumonia vaccination: A case study in Narok district of Kenya

CBPP is an important transboundary disease in sub-Saharan Africa whose control is urgent. Participatory data collection involving 52 focus group discussions in 37 village clusters and key informant interviews, a cross-sectional study involving 232 households and a post-vaccination follow up invol...


Kairu-Wanyoike, S.W.Kiara, Henry K.Heffernan, C.L.Kaitibie, S.Gitau, G.K.McKeever, Declan J.Taylor, N.M.[Control of Contagious Bovine Pleuropneumonia: Knowledge, attitudes, perceptions and practices in Narok District of Kenya]Control of Contagious Bovine Pleuropneumonia: Knowledge, attitudes, perceptions and practices in Narok District of Kenya

Contagious Bovine Pleuropneumonia (CBPP) is an economically important trans-boundary cattle disease which affects food security and livelihoods. A conjoint analysis-contingent valuation was carried out on 190 households in Narok District of Kenya to measure willingness to pay (WTP) and demand for...


Kairu-Wanyoike, S.W.Kaitibie, S.Heffernan, C.L.Taylor, N.M.Gitau, G.K.Kiara, Henry K.McKeever, Declan J.[Willingness to pay for Contagious Bovine Pleuropneumonia vaccination in Narok South District of Kenya]Willingness to pay for Contagious Bovine Pleuropneumonia vaccination in Narok South District of Kenya

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