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Journal Article 2011-09-29

Autor: Nkando, I. Ndinda, J. Kuria, J. Naessens, Jan Mbithi, F. Schnier, C. Gicheru, M. McKeever, Declan J. Wesonga, H.O.

A live, attenuated vaccine is currently the only viable option to control of CBPP in Africa. It has been suggested that simple modifications to current vaccines and protocols might improve efficacy in the field. In this report we compared the current vaccine formulation with a buffered preparatio...

Enlace original: https://cgspace.cgiar.org/handle/10568/16450

Investigación en Agricultura
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Nkando, I. ,  Ndinda, J. ,  Kuria, J. ,  Naessens, Jan ,  Mbithi, F. ,  Schnier, C. ,  Gicheru, M. ,  McKeever, Declan J. ,  Wesonga, H.O. ,  [Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle] ,  Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle
Journal Article 1997

Autor: Ballingall, K.T. Luyai, A. McKeever, Declan J.

We describe the development of a polymerase chain reaction (PCR)-based approach for analysis of genetic diversity at the DQA loci in African Bos indicus and Bos Taurus cattle. This approach, equally effective in European and Asian cattle breeds, detects the presence or absence of DAQ1 and most du...

Enlace original: https://cgspace.cgiar.org/handle/10568/32942

Investigación en Agricultura
DNA
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Ballingall, K.T. ,  Luyai, A. ,  McKeever, Declan J. ,  [Analysis of genetic diversity at the DQA loci in African cattle: Evidence for a BoLA-DQA3 locus] ,  Analysis of genetic diversity at the DQA loci in African cattle: Evidence for a BoLA-DQA3 locus
Journal Article 1999

Autor: Ellis, S.A. Holmes, E.C. Staines, K.A. Smith, K.B. Stear, M.J. McKeever, Declan J. MacHugh, Niall D. Morrison, W. Ivan

Analysis of cattle major histocompatibility complex (MHC) (BoLA) class I gene expression using serological and biochemical methods has demonstrated a high level of polymorphism. However, analysis of class I cDNA sequences has failed to produce conclusive evidence concerning the number and nature ...

Enlace original: https://cgspace.cgiar.org/handle/10568/32939

Investigación en Agricultura
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Ellis, S.A. ,  Holmes, E.C. ,  Staines, K.A. ,  Smith, K.B. ,  Stear, M.J. ,  McKeever, Declan J. ,  MacHugh, Niall D. ,  Morrison, W. Ivan ,  [Variation in the number of expressed MHC genes in different cattle class I haplotypes] ,  Variation in the number of expressed MHC genes in different cattle class I haplotypes
Journal Article 2001

Autor: Ballingall, K.T. Waibochi, L. Homes, E.C. Woelk, C.H. MacHugh, Niall D. Lutje, V. McKeever, Declan J.

Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. Taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with...

Enlace original: https://cgspace.cgiar.org/handle/10568/32940

Investigación en Agricultura
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Ballingall, K.T. ,  Waibochi, L. ,  Homes, E.C. ,  Woelk, C.H. ,  MacHugh, Niall D. ,  Lutje, V. ,  McKeever, Declan J. ,  [The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection] ,  The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection
Journal Article 1998

Autor: Honda, Y. Waithaka, M.M. Taracha, E.L.N. Duchateau, L. Musoke, A.J. McKeever, Declan J.

To evaluate vaccinia virus as a delivery system for recombinant antigen in cattle, calves were immunized with a recombinant vaccinia virus (rVV) expressing the sporozoite surface antigen (p67) of Theileria parva (V-67) combined with those expressing bovine IL-4 (V-IL4) or IL-2 (V-IL2). The anti-p...

Enlace original: https://cgspace.cgiar.org/handle/10568/29820

Investigación en Agricultura
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Honda, Y. ,  Waithaka, M.M. ,  Taracha, E.L.N. ,  Duchateau, L. ,  Musoke, A.J. ,  McKeever, Declan J. ,  [Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection] ,  Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection
Conference Paper 1988

Autor: Morrison, W. Ivan MacHugh, Niall D. Bensaid, A.M. Goddeeris, B.M. Teale, A.J. McKeever, Declan J.
Enlace original: https://cgspace.cgiar.org/handle/10568/50096

Investigación en Agricultura
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Morrison, W. Ivan ,  MacHugh, Niall D. ,  Bensaid, A.M. ,  Goddeeris, B.M. ,  Teale, A.J. ,  McKeever, Declan J. ,  [A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers] ,  A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers
Journal Article 1997

Autor: McKeever, Declan J. Nyanjui, J.K. Ballingall, K.T.

The protozoan parasite Theileria parva infects and transforms bovine lymphocytes, giving rise to a fatal lympho-proliferative condition known as East Coast fever. Although immune cattle mount strong cytolytic T. lymphocyte responses to the parasite, naive animals appear unable to respond and deve...

Enlace original: https://cgspace.cgiar.org/handle/10568/33091

Investigación en Agricultura
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McKeever, Declan J. ,  Nyanjui, J.K. ,  Ballingall, K.T. ,  [In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages] ,  In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages
Journal Article 2002

Autor: Mwangi, D.M. McKeever, Declan J. Nyanjui, J.K. Barbet, A.F. Mahan, S.M.

There is growing evidence that immunity of cattle to Cowdria ruminantium infection is mediated by T lymphocytes. C. ruminantium antigens that stimulate these responses are therefore of considerable importance to the development of a sub-unit vaccine against the disease. We have examined T cell re...

Enlace original: https://cgspace.cgiar.org/handle/10568/33223

Investigación en Agricultura
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Mwangi, D.M. ,  McKeever, Declan J. ,  Nyanjui, J.K. ,  Barbet, A.F. ,  Mahan, S.M. ,  [Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent] ,  Immunisation of cattle against heartwater by infection with Cowdria ruminantium elicits T lymphocytes that recognise major antigenic proteins 1 and 2 of the agent
Journal Article 1998

Autor: Honda, Y. Matsubara, Y. Morzaria, S.P. McKeever, Declan J.

Theileria parva is the causal agent of East Coast fever (ECF), a fatal disease of cattle characterized by pyrexia, transient lymphadenopathy and panleukopenia. We have evaluated monoclonal antibodies (mAb) against three distinct antigens (p67, PIM and p32) of the parasite as immunohistological re...

Enlace original: https://cgspace.cgiar.org/handle/10568/33247

Investigación en Agricultura
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Honda, Y. ,  Matsubara, Y. ,  Morzaria, S.P. ,  McKeever, Declan J. ,  [Immunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes] ,  Immunohistochemical detection of parasite antigens in Theileria parva-infected bovine lymphocytes
Journal Article 2000

Autor: Ballingall, K.T. Mwangi, D.M. MacHugh, Niall D. Taracha, E.L.N. Totte, P. McKeever, Declan J.

We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33010

Investigación en Agricultura
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Ballingall, K.T. ,  Mwangi, D.M. ,  MacHugh, Niall D. ,  Taracha, E.L.N. ,  Totte, P. ,  McKeever, Declan J. ,  [A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells] ,  A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells

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