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T cells bearing the gamma delta antigen receptor (gamma delta T cells) can constitute up to 50 percent of T cells in the peripheral blood and lymphoid organs of young cattle. We present data showing that gamma delta T cells are involved in immune responses against Theileria parva. Gamma delta T c...


Daubenberger, C.A.Taracha, E.L.N.Gaidulis, L.Davis, W.C.McKeever, Declan J.[Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva]Bovine gamma delta T cell responses to the intracellular protozoan parasite Theileria parva
Goddeeris, B.M.Dunlap, S.Innes, E.A.McKeever, Declan J.[A simple and efficient method for purifying and quantifying schizonts from Theileria parva-infected cells]A simple and efficient method for purifying and quantifying schizonts from Theileria parva-infected cells

To evaluate vaccinia virus as a delivery system for recombinant antigen in cattle, calves were immunized with a recombinant vaccinia virus (rVV) expressing the sporozoite surface antigen (p67) of Theileria parva (V-67) combined with those expressing bovine IL-4 (V-IL4) or IL-2 (V-IL2). The anti-p...


Honda, Y.Waithaka, M.M.Taracha, E.L.N.Duchateau, L.Musoke, A.J.McKeever, Declan J.[Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection]Delivery of the Theileria parva p67 antigen to cattle using recombinant vaccinia virus: IL-2 enhances protection
Goddeeris, B.M.Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[East Coast Fever (Theileria parva). Cell-mediated immunity and protection]East Coast Fever (Theileria parva). Cell-mediated immunity and protection

The protozoan parasite Theileria parva infects and transforms bovine lymphocytes, giving rise to a fatal lympho-proliferative condition known as East Coast fever. Although immune cattle mount strong cytolytic T. lymphocyte responses to the parasite, naive animals appear unable to respond and deve...


McKeever, Declan J.Nyanjui, J.K.Ballingall, K.T.[In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages]In vitro infection with Theileria parva is associated with IL10 expression in all bovine lymphocyte lineages

Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...


McKeever, Declan J.Taracha, E.L.N.Morrison, W. IvanMusoke, A.J.Morzaria, S.P.[Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies]Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies

A first-gneration subunit vaccine for East Coast fever based on the Theileria parva p67 sporozoite surface antigen is entering preliminary field trials. Intensive efforts are also focused on the identification of a schizont-specific omponen for incorporation in a second-generation multi-component...


McKeever, Declan J.Morrison, W. Ivan[Invited review Novel vaccines against Theileria parva: prospects for sustainability]Invited review Novel vaccines against Theileria parva: prospects for sustainability

We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...


Ballingall, K.T.Mwangi, D.M.MacHugh, Niall D.Taracha, E.L.N.Totte, P.McKeever, Declan J.[A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells]A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells
McKeever, Declan J.Morrison, W. Ivan[Theileria parva: The nature of the immune response and its significance for immunoprophylaxis]Theileria parva: The nature of the immune response and its significance for immunoprophylaxis
Pain, A.Renauld, H.Berriman, M.Murphy, L.Yeats, C.A.Weir, W.Kerhornou, A.Aslett, M.Bishop, Richard P.Bouchier, C.Bouchier, C.Cochet, M.Coulson, R.M.R.Cronin, A.Villiers, Etienne P. deFraser, A.Fosker, N.Gardner, M.Goble, A.Griffiths-Jones, S.Harris, D.E.Katzer, F.Larke, N.Lord, A.Maser, P.McKellar, S.Mooney, P.Morton, F.Nene, VishvanathO'Neil, S.Price, C.Quail, M.A.Rabbinowitsch, E.Rawlings, N.D.Rutter, S.Saunders, D.Seeger, K.Shah, TushaarSquares, R.Squares, S.Tivey, A.Walker, A.R.Woodward, J.Dobbelaere, D.A.E.Langsley, G.Rajandream, M.A.McKeever, Declan J.Shiels, B.Tait, A.Barrell, B.Hall, N.[Genome of the host-cell transforming parasite Theileria annulata compared with T. parva]Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

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