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The indirect MAP 1B ELISA based on the recombinant MAP 1B fragment of the immunodominant MAP 1 protein of Ehrlichia ruminantium is considered to be the most sensitive and specific assay for the serodiagnosis of heartwater. In this study, we evaluated its reliability in detecting exposure to E....


Peter, T.F.O'Callaghan, C.J.Medley, G.F.Perry, Brian D.Semu, S.M.Mahan, S.M.[Population-based evaluation of the Ehrlichia ruminantium MAP 1B indirect ELISA]Population-based evaluation of the Ehrlichia ruminantium MAP 1B indirect ELISA

A mathematical description of the transmission dynamics of the tick-borne infection Cowdria ruminantium in commercial beef enterprises in Zimbabwe was used to consider the potential impact of a candidate vaccine to prevent heartwater. The important characteristics of the vaccine were (1) a delay ...


O'Callaghan, C.J.Medley, G.F.Peter, T.F.Mahan, S.M.Perry, Brian D.[Predicting the effect of vaccination on the transmission dynamics of heartwater (Cowdria ruminantium infection)]Predicting the effect of vaccination on the transmission dynamics of heartwater (Cowdria ruminantium infection)

As part of a series of studies associated with the development of improved vaccines for heartwater (a tick-borne disease of ruminant livestock caused by Cowdria ruminantium), field surveys were carried out to assess losses associated with the disease and the costs associated with controlling it i...


Chamboko, TafireyiMukhebi, A.W.Callaghan, C.J.O.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[The control of heartwater on large-scale commercial and smallholder farms in Zimbabwe]The control of heartwater on large-scale commercial and smallholder farms in Zimbabwe

Heartwater, caused by the rickettsial organism Cowdria ruminantium, is a serious constraint to livestock development in much of sub-Saharan Africa. Traditionally, the disease has been controlled by the use of chemical acaricides to control the vector tick. The University of Florida/USAID-supporte...


Mukhebi, A.W.Chamboko, TafireyiO'Callaghan, C.J.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe]An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe

Adult Amblyomma hebraeum ticks, the principle vector of heartwater (cowdriosis) of domestic ruminants in southern Africa, were collected in pheromone traps placed in Kruger National Park, an exclusively wildlife sanctuary in South Africa. These ticks transmitted Cowdria ruminantium, the rickettsi...


Peter, T.F.Bryson, N.R.Perry, Brian D.O'Callaghan, C.J.Medley, G.F.Smith, G.E.Mlambo, G.Horak, I.G.Burridge, M.J.Mahan, S.M.[Cowdria ruminantium infection in ticks in the Kruger National Park]Cowdria ruminantium infection in ticks in the Kruger National Park

Analysis of the transmission dynamics of Cowdria ruminantium, the tick-borne rickettsial agent of heartwater in ruminants, requires accurate measures of infection in vector populations. To obtain these, Amblyomma hebraeum ticks were collected at two heartwater-endemic locations in the lowveld and...


Peter, T.F.Perry, Brian D.O'Callaghan, C.J.Medley, G.F.Mlambo, G.Barbet, A.F.Mahan, S.M.[Prevalence of Cowdria ruminantium infection in Amblyomma hebraeum ticks from heartwater-endemic areas of Zimbabwe]Prevalence of Cowdria ruminantium infection in Amblyomma hebraeum ticks from heartwater-endemic areas of Zimbabwe

In order to assess the economic impact of heartwater (Cowdria ruminantium infection) and model the impact of improved vaccines against the disease, a field study was conducted to provide data on livestock productivity indicators in Zimbabwe. Cross-sectional studies were performed in the two main ...


Chamboko, TafireyiMukhebi, A.W.O'Callaghan, C.J.Peter, T.F.Kruska, R.L.Medley, G.F.Mahan, S.M.Perry, Brian D.[Heartwater and the economics of livestock production on large scale commercial and smallholder farms in Zimbabwe]Heartwater and the economics of livestock production on large scale commercial and smallholder farms in Zimbabwe

The tick vectors of heartwater (Cowdria ruminantium infection) in Zimbabwe, Amblyomma hebraeum and Amblyomma variegatum, historically were believed to be confined to the low-lying regions of the south and north-west of the country. However, country-wide surveys performed in 1975-1980 and 1988-199...


Peter, T.F.Perry, Brian D.O'Callaghan, C.J.Medley, G.F.Shumba, W.Madzima, W.Burridge, M.J.Mahan, S.M.[Distributions of the vectors of heartwater, Amblyomma hebraeum and amblyomma variegatum (Acari: Ixodidae), in Zimbabwe]Distributions of the vectors of heartwater, Amblyomma hebraeum and amblyomma variegatum (Acari: Ixodidae), in Zimbabwe

Heartwater, caused by the rickettsial organism Cowdria ruminantium and transmitted by ticks of the genus Amblyomma, is considered to be the most important tick-borne disease of cattle in southern Africa, and is second only in importance to East Coast fever (theileriosis) in eastern Africa. This p...


O'Callaghan, C.J.Medley, G.F.Peter, T.F.Perry, Brian D.[Modelling the transmission dynamics of Cowdria ruminantium: Supporting the case for endemic stability]Modelling the transmission dynamics of Cowdria ruminantium: Supporting the case for endemic stability

Heartwater, an infectious disease of ruminants caused by the rickettsia Cowdria ruminantium (transmitted by ixodid ticks of the genus Amblyomma and vertically), severely constrains livestock production throughout sub-Saharan Africa. Its epidemiology varies from epidemics with high mortality (on i...


O'Callaghan, C.J.Medley, G.F.Peter, T.F.Mahan, S.M.Perry, Brian D.[Predicting the effect of vaccination of the transmission dynamics of heartwater (Cowdria ruminantium infection)]Predicting the effect of vaccination of the transmission dynamics of heartwater (Cowdria ruminantium infection)

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