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The mechanisms whereby trypanotolerant N'Dama cattle control infection with Trypanosoma congolense are unknown. Previous studies have suggested that the monocytes of N'Dama cattle are more highly activated during infection than those of trypanosus ceptible Boan cattle. However, we have recently r...


Taylor, K.Mertens, B.Lutje, V.Saya, R.[Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10]Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10

African trypanosomes are important pathogens of both humans and livestock. We investigated the association of cytokine responses with disease susceptibility in Trypanosoma congolense-infected cattle. Changes in interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-12 p40, tumor necrosis factor-alph...


Mertens, B.Taylor, K.Muriuki, C.Rocchi, M.[Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4]Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4

Trypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic secur...


Taylor, K.A.Mertens, B.[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]Immune responses of cattle to African trypanosomes: Protective or pathogenic?

Infection with African trypanosomes causes the diseases sleeping sickness in humans and nagana in cattle in sub-Saharan Africa. Suppression of cellular immune responses is a feature of trypanosomiasis in bovine, human, and murine hosts. Some aspects of immunosuppression in the murine model are me...


Taylor, K.Lutje, V.Mertens, B.[Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression]Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression

The Development of vaccine against the African trypanosomiasis passes through the identification process of invariant component. This process targets the prevention of infection or diseases related to it. Immunity suppression in almost a universal feature of infection and represents probably an e...


Taylor, K.Mertens, B.Rocchi, M.Elson, L.[Immune suppression during bovine trypanosomosis]Immune suppression during bovine trypanosomosis

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