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Neurons encode electrical signals with critically tuned voltage-gated ion channels and enzymes. Dedicated voltage sensor domains (VSDs) in these membrane proteins activate coordinately with an unresolved structural change. Such change conveys the transmembrane translocation of four positively cha...


Díaz-Franulic, I.González-Pérez, V.Moldenhauer, H.Navarro-Quezada, N.Naranjo, D.[Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels]Gating-induced large aqueous volumetric remodeling and aspartate tolerance in the voltage sensor domain of Shaker K+ channels

Reconciling protein functional data with crystal structure is arduous because rare conformations or crystallization artifacts occur. Here we present a tool to validate the dimensions of open pore structures of potassium-selective ion channels. We used freely available algorithms to calculate the ...


Moldenhauer, H.Diaz-Franulic, I.Gonzalez-Nilo, F.Naranjo, D.[Effective pore size and radius of capture for K+ ions in K-channels]Effective pore size and radius of capture for K+ ions in K-channels

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