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Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been deMonstrated to target a variety of other proteins unrelated to the chromatin environment. In this context, our present work demonstrates that the pharmacological or genetic abrogation of HDAC6 in pri...


Lienlaf, M.Perez-Villarroel, P.Knox, T.Pabon, M.Sahakian, E.Powers, J.Woan, K.V.Lee, C.Cheng, F.Deng, S.Smalley, K.S.M.Montecino, M.Kozikowski, A.Pinilla-Ibarz, J.Sarnaik, A.Seto, E.Weber, J.Sotomayor, E.M.Villagra, A.[Essential role of HDAC6 in the regulation of PD-L1 in melanoma]Essential role of HDAC6 in the regulation of PD-L1 in melanoma

The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increas...


Díaz-Jiménez, D.Núñez, L.De La Fuente, M.Dubois-Camacho, K.Sepúlveda, H.Montecino, M.Torres-Riquelme, A.García-González, P.Chnaiderman, J.Vossenkamper, A.MacDonald, T.T.Simian, D.González, M.Cidlowski, J.A.Quera, R.Hermoso, M.A.[A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis]A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis

The anuran Rhinella spinulosa is distributed along the Andes Range at altitudes that undergo wide daily and seasonal variation in temperature. One of the populations inhabits geothermal streams, a stable environment that influences life history traits such as the timing of metamorphosis. To inves...


Pastenes, L.Valdivieso, C.Di Genova, A.Travisany, D.Hart, A.Montecino, M.Orellana, A.Gonzalez, M.Gutiérrez, R.A.Allende, M.L.Maass, A.Méndez, M.A.[Global gene expression analysis provides insight into local adaptation to geothermal streams in tadpoles of the Andean toad Rhinella spinulosa]Global gene expression analysis provides insight into local adaptation to geothermal streams in tadpoles of the Andean toad Rhinella spinulosa

Expression of the scaffolding protein Caveolin-1 (CAV1) enhances migration and invasion of metastatic cancer cells. Yet, CAV1 also functions as a tumor suppressor in early stages of cancer, where expression is suppressed by epigenetic mechanisms. Thus, we sought to identify stimuli/mechanisms tha...


Díaz-Valdivia, N.I.Calderón, C.C.Díaz, J.E.Lobos-González, L.Sepulveda, H.Ortíz, R.J.Martinez, S.Silva, V.Maldonado, H.J.Silva, P.Wehinger, S.Burzio, V.A.Torres, V.A.Montecino, M.Leyton, L.Quest, A.F.G.[Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells]Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells

We describe an emerging initiative - the 'Functional Annotation of All Salmonid Genomes' (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ancestor, to develop an integrative understanding of the functional genomic b...


Macqueen, D.J.Primmer, C.R.Houston, R.D.Nowak, B.F.Bernatchez, L.Bergseth, S.Davidson, W.S.Gallardo-Escárate, C.Goldammer, T.Guiguen, Y.Iturra, P.Kijas, J.W.Koop, B.F.Lien, S.Maass, A.Martin, S.A.M.McGinnity, P.Montecino, M.Naish, K.A.Nichols, K.M.Ólafsson, K.Omholt, S.W.[Functional Annotation of All Salmonid Genomes (FAASG): An international initiative supporting future salmonid research, conservation and aquaculture]Functional Annotation of All Salmonid Genomes (FAASG): An international initiative supporting future salmonid research, conservation and aquaculture

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