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The relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses ...
Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of ...
The importance of T-cell-mediate immune responses in the control of intracellular protozoan parasites is now well established 1-3. The killing of parasitized cells by T cells and cytokine-mediated effects on growth and viability of the intracellular parasites have both been implicated as effector...
Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...
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