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Trypanosoma brucei contain a serine oligopeptidase (OP-Tb) that is released into (and remains active in) the blood of trypanosome-infected animals. Here a similar enzyme from Trypanosoma congolense is described. This oligopeptidase, called OP-Tc, was purified using three-phase partitioning, and i...


Morty, R.E.Authié, E.Troeberg, L.Lonsdale-Eccles, J.D.Coetzer, T.H.T.[Purification and characterisation of a typsin-like serine oligo peptidase from Trypanosoma congolense]Purification and characterisation of a typsin-like serine oligo peptidase from Trypanosoma congolense

Peptidases of parasitic protozoans are emerging as novel virulence factors and therapeutic targets in parasitic infections. A trypanosome-derived aminopeptidase that exclusively hydrolysed substrates with Glp (pyroglutamic acid) in P1 was purified 9248-fold from the plasma of rats infected with T...


Morty, R.E.Bulau, P.Pelle, RogerWilki, S.Abe, K.[Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts]Pyroglutamyl peptidase type I from Trypanosoma brucei: A new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts

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