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The major sporozoite surface antigen of Theileria annulata (SPAG-1) is a candidate for inclusion in a subunit vaccine. In this paper we summarize the results of 4 vaccination experiments using recombinant SPAG-1 expressed in different systems and presented in different adjuvants. The antigen has ...


Boulter, N.Brown, D.Wilkie, G.Williamson, S.Kirvar, E.Knight, P.Glass, E.Campbell, J.Morzaria, S.P.Nene, VishvanathMusoke, A.J.Oliveria, C. deGubbels, M.J.Jongejan, F.Hall, R.[Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems]Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems

Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen

Mukhebi, A.W.Morzaria, S.P.Perry, Brian D.[Economics of an East Coast Fever immunization trial at the Kenya coast]Economics of an East Coast Fever immunization trial at the Kenya coast
Morzaria, S.P.[A systematic approach to East Coast Fever immunization in the Kilifi District of the Kenya coast]A systematic approach to East Coast Fever immunization in the Kilifi District of the Kenya coast

Background Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod vector, which involves an obligate sexual cy...


Henson, S.Bishop, Richard P.Morzaria, S.P.Spooner, P.R.Pelle, RogerPoveda, L.Ebeling, M.Kung, E.Certa, U.Daubenberger, C.A.Weihong Qi[High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing]High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing

The Infection and Treatment Method (ITM) of vaccination against the apicomplexan parasite Theileria parva has been used since the early 1970s and is still the only commercially available vaccine to combat the fatal bovine disease, East Coast fever (ECF). The disease is tick-transmitted and result...


Patel, EktaMwaura, S.Kiara, Henry K.Morzaria, S.P.Peters, A.Toye, Philip G.[Production and dose determination of the Infection and Treatment Method (ITM) Muguga cocktail vaccine used to control East Coast fever in cattle]Production and dose determination of the Infection and Treatment Method (ITM) Muguga cocktail vaccine used to control East Coast fever in cattle
Irvin, A.D.Morzaria, S.P.[Report on a Mission to Isolate Theileria parva in Zanzibar and to Assess the Feasability of Conducting Pilot Immunization Trials Against East Coast Fever]Report on a Mission to Isolate Theileria parva in Zanzibar and to Assess the Feasability of Conducting Pilot Immunization Trials Against East Coast Fever
Woodford, J.D.Gayer, J.G.Dolan, T.T.Morzaria, S.P.[An East Coast fever immunization trial on Pemba Island, Zanzibar]An East Coast fever immunization trial on Pemba Island, Zanzibar
Mutugi, J.J.M.Young, A.S.Kariuki, D.P.Ole Tameno, J.M.Morzaria, S.P.[Epidemiological observations on theileriosis following field immunisation using infection and treatment]Epidemiological observations on theileriosis following field immunisation using infection and treatment
Chumo, R.S.C.Irvin, A.D.Morzaria, S.P.Katende, J.Purnell, R.E.[Long-acting oxytetracycline prophylaxis to protect susceptible cattle introduced into an area of Kenya with endemic East Coast fever]Long-acting oxytetracycline prophylaxis to protect susceptible cattle introduced into an area of Kenya with endemic East Coast fever

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