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The major sporozoite surface antigen of Theileria annulata (SPAG-1) is a candidate for inclusion in a subunit vaccine. In this paper we summarize the results of 4 vaccination experiments using recombinant SPAG-1 expressed in different systems and presented in different adjuvants. The antigen has ...


Boulter, N.Brown, D.Wilkie, G.Williamson, S.Kirvar, E.Knight, P.Glass, E.Campbell, J.Morzaria, S.P.Nene, VishvanathMusoke, A.J.Oliveria, C. deGubbels, M.J.Jongejan, F.Hall, R.[Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems]Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems

Background Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod vector, which involves an obligate sexual cy...


Henson, S.Bishop, Richard P.Morzaria, S.P.Spooner, P.R.Pelle, RogerPoveda, L.Ebeling, M.Kung, E.Certa, U.Daubenberger, C.A.Weihong Qi[High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing]High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing

The Infection and Treatment Method (ITM) of vaccination against the apicomplexan parasite Theileria parva has been used since the early 1970s and is still the only commercially available vaccine to combat the fatal bovine disease, East Coast fever (ECF). The disease is tick-transmitted and result...


Patel, EktaMwaura, S.Kiara, Henry K.Morzaria, S.P.Peters, A.Toye, Philip G.[Production and dose determination of the Infection and Treatment Method (ITM) Muguga cocktail vaccine used to control East Coast fever in cattle]Production and dose determination of the Infection and Treatment Method (ITM) Muguga cocktail vaccine used to control East Coast fever in cattle
Mutugi, J.J.M.Young, A.S.Kariuki, D.P.Ole Tameno, J.M.Morzaria, S.P.[Epidemiological observations on theileriosis following field immunisation using infection and treatment]Epidemiological observations on theileriosis following field immunisation using infection and treatment
Chumo, R.S.C.Irvin, A.D.Morzaria, S.P.Katende, J.Purnell, R.E.[Long-acting oxytetracycline prophylaxis to protect susceptible cattle introduced into an area of Kenya with endemic East Coast fever]Long-acting oxytetracycline prophylaxis to protect susceptible cattle introduced into an area of Kenya with endemic East Coast fever

Bovine theileriosis caused by Theileria parva continues to be a major economic problem in many parts of Eastern, Southern, and Central Africa. Due to the unsustainable nature or the present control method-using toxic acaricides to kill ticks - alternative control methods are being sought. Live va...


Morzaria, S.P.Nene, VishvanathBishop, Richard P.Musoke, A.J.[Vaccines against Theileria parva]Vaccines against Theileria parva

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