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Flach, E.J.Shambwana, I.Dolan, T.T.Kassim, A.Pedersen, H.Glass, M.Morzaria, S.P.[East Coast Fever immunization trials on Unguja Island, Zanzibar]East Coast Fever immunization trials on Unguja Island, Zanzibar

Mutugi, J.J.M.Young, A.S.Maritim, A.C.Ndungu, S.G.Linyonyi, A.Ngumi, P.N.Mining, S.K.Leitch, B.L.Stagg, D.A.Grootenhuis, J.G.Kariuki, D.P.Morzaria, S.P.Dolan, T.T.[Parasite stocks used for East Coast Fever immunization in Kenya]Parasite stocks used for East Coast Fever immunization in Kenya

The infection-and-treatment method (ITM) for immunization of cattle against East Coast fever has historically been used only on a limited scale because of logistical and policy constraints. Recent large-scale deployment among pastoralists in Tanzania has stimulated demand. Concurrently, a suite o...


Giulio, Giuseppe diLynen, GodelieveMorzaria, S.P.Oura, C.Bishop, Richard P.[Live immunization against East Coast fever - current status]Live immunization against East Coast fever - current status
Mukhebi, A.W.Morzaria, S.P.Perry, Brian D.Dolan, T.T.Norval, R.A.I.[Cost analysis of immunization of East Coast fever by the infection and treatment method]Cost analysis of immunization of East Coast fever by the infection and treatment method

Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These anti...


Hall, R.Boulter, N.R.Brown, C.G.D.Wilkie, G.Kirvar, E.Nene, VishvanathMusoke, A.J.Glass, E.J.Morzaria, S.P.[Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva]Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva

Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...


Bishop, Richard P.Nene, VishvanathStaeyert, J.Rowlands, G.J.Nyanjui, J.Osaso, J.Morzaria, S.P.Musoke, A.J.[Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites]Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites

Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...


Musoke, A.J.Rowlands, G.J.Nene, VishvanathNyanjui, J.Katende, J.Spooner, P.R.Mwaura, S.Odongo, D.Nkonge, C.Mbogo, S.Bishop, Richard P.Morzaria, S.P.[Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge]Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge

Rhipicephalus appendiculatus adult ticks, collected int he field from zebu (Bos indicus) and exotic (Bos tarus) cattle with high antibody titres to Theileria parva schizont antigen, transmitted Theileria parva infection typical of East Coast fever to susceptible cattle. Uninfected R. appendiculat...


Kariuki, D.P.Young, A.S.Morzaria, S.P.Lesan, A.C.Mining, S.K.Omwoyo, P.Wafula, J.L.M.Molyneux, D.H.[Theileria parva carrier state in naturally infected and artificially immunized cattle]Theileria parva carrier state in naturally infected and artificially immunized cattle
Morzaria, S.P.Irvin, A.D.Wathanga, J.D'Souza, D.Katende, J.M.Young, A.S.Scott, J.R.Gettinby, G.[The effect of East Coast fever immunisation and different acaricidal treatments on the productivity of beef cattle]The effect of East Coast fever immunisation and different acaricidal treatments on the productivity of beef cattle

Results of an experiment conducted to determine reactions following infection of cattle with Theileria parva (Boleni) challenged with T.Parva (Muguga), T.Parva (Marikebuni), T.P., Parva (Mariakani) and T.lawrencei (Nanyuti).


Irvin, A.D.Morzaria, S.P.Munatswa, F.C.Norval, R.A.I.[Immunization of cattle with a Theileria parva bovis stock from Zimbabwe protects against challenge with virulent Theileria parva parva and Theileria parva lawrencei stocks from Kenya]Immunization of cattle with a Theileria parva bovis stock from Zimbabwe protects against challenge with virulent Theileria parva parva and Theileria parva lawrencei stocks from Kenya

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