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Journal Article 2002-03-15

Autor: Skilton, Robert A. Bishop, Richard P. Katende, J.M. Mwaura, S. Morzaria, S.P.

An improved Theileria parva DNA detection assay based on the polymerase chain reaction (PCR) using primers derived from the 104 kDa antigen (p104) gene was developed to detect parasite DNA in blood spots on filter paper. The specificity of the assay was validated using DNA from a wide range of ca...

Enlace original: https://cgspace.cgiar.org/handle/10568/21168

Investigación en Agricultura
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Skilton, Robert A. ,  Bishop, Richard P. ,  Katende, J.M. ,  Mwaura, S. ,  Morzaria, S.P. ,  [The persistence of Theileria parva infection in cattle immunised using two stocks which differ in their ability to induce a carrier state: Analysis using a novel blood spot PCR assay] ,  The persistence of Theileria parva infection in cattle immunised using two stocks which differ in their ability to induce a carrier state: Analysis using a novel blood spot PCR assay
Journal Article 1999

Autor: Morzaria, S.P. Katende, J. Musoke, A.J. Nene, Vishvanath Skilton, Robert A. Bishop, Richard P.

Tick-borne diseases (TBDs) are a major economic constraint to livestock production in sub-Saharan Africa. ILRI is focussing on developing a range of products, such as vaccines, diagnostics and decision support services to underpin improved control programmes against these diseases. We have develo...

Enlace original: https://cgspace.cgiar.org/handle/10568/29383

Investigación en Agricultura
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Morzaria, S.P. ,  Katende, J. ,  Musoke, A.J. ,  Nene, Vishvanath ,  Skilton, Robert A. ,  Bishop, Richard P. ,  [Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa] ,  Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa
Journal Article 2004

Autor: Bishop, Richard P. Musoke, A.J. Morzaria, S.P. Gardner, M. Nene, Vishvanath

Theileria are economically important, intra-cellular protozoa, transmitted by ixodid ticks, which infect wild and domestic ruminants. In the mammalian host, parasites infect leukocytes and erythrocytes. In the arthropod vector they develop in gut epithelial cells and salivary glands. All four int...

Enlace original: https://cgspace.cgiar.org/handle/10568/33095

Investigación en Agricultura
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Bishop, Richard P. ,  Musoke, A.J. ,  Morzaria, S.P. ,  Gardner, M. ,  Nene, Vishvanath ,  [Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks] ,  Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
Journal Article 2000

Autor: Skilton, Robert A. Musoke, A.J. Nene, Vishvanath Wasawo, D.P.S. Wells, C.W. Spooner, P.R. Bishop, Richard P. Osaso, J. Nkonge, C. Latif, A. Morzaria, S.P.

Theileria are tick-transmitted, haemoprotozoan parasites infecting wild and domestic ungulates throughout many areas of the world. The most economically important species are T. parva and T. annulata which are pathogenic to cattle, and T. lestoquardi (syn hirci) which is pathogenic to sheep and g...

Enlace original: https://cgspace.cgiar.org/handle/10568/33064

Investigación en Agricultura
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Skilton, Robert A. ,  Musoke, A.J. ,  Nene, Vishvanath ,  Wasawo, D.P.S. ,  Wells, C.W. ,  Spooner, P.R. ,  Bishop, Richard P. ,  Osaso, J. ,  Nkonge, C. ,  Latif, A. ,  Morzaria, S.P. ,  [Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen] ,  Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen
Journal Article 2000

Autor: Hall, R. Boulter, N.R. Brown, C.G.D. Wilkie, G. Kirvar, E. Nene, Vishvanath Musoke, A.J. Glass, E.J. Morzaria, S.P.

Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These anti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33093

Investigación en Agricultura
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Hall, R. ,  Boulter, N.R. ,  Brown, C.G.D. ,  Wilkie, G. ,  Kirvar, E. ,  Nene, Vishvanath ,  Musoke, A.J. ,  Glass, E.J. ,  Morzaria, S.P. ,  [Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva] ,  Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva
Journal Article 1999

Autor: McKeever, Declan J. Taracha, E.L.N. Morrison, W. Ivan Musoke, A.J. Morzaria, S.P.

Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...

Enlace original: https://cgspace.cgiar.org/handle/10568/33104

Investigación en Agricultura
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McKeever, Declan J. ,  Taracha, E.L.N. ,  Morrison, W. Ivan ,  Musoke, A.J. ,  Morzaria, S.P. ,  [Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies] ,  Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies
Journal Article 2003

Autor: Bishop, Richard P. Nene, Vishvanath Staeyert, J. Rowlands, G.J. Nyanjui, J. Osaso, J. Morzaria, S.P. Musoke, A.J.

Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...

Enlace original: https://cgspace.cgiar.org/handle/10568/33215

Investigación en Agricultura
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Bishop, Richard P. ,  Nene, Vishvanath ,  Staeyert, J. ,  Rowlands, G.J. ,  Nyanjui, J. ,  Osaso, J. ,  Morzaria, S.P. ,  Musoke, A.J. ,  [Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites] ,  Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites
Journal Article 1995

Autor: Nene, Vishvanath Inumaru, S. McKeever, Declan J. Morzaria, S.P. Shaw, M. Musoke, A.J.

Previous data showed that six out of a group of nine cattle inoculated with NS1-p67, a recombinant form of a 67-KDa Theileria parva sporozoite surface protein, were immune to East Coast fever. This bacterialy expressed antigen encoded all 709 amino acid residues of p67 fused to the C-terminal end...

Enlace original: https://cgspace.cgiar.org/handle/10568/28744

Investigación en Agricultura
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Nene, Vishvanath ,  Inumaru, S. ,  McKeever, Declan J. ,  Morzaria, S.P. ,  Shaw, M. ,  Musoke, A.J. ,  [Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle] ,  Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle
Journal Article 1999

Autor: Nene, Vishvanath Gobright, E.I. Bishop, Richard P. Morzaria, S.P. Musoke, A.J.

A stage-specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. By Pepscan analysis with a series of overlapping synthetic p67 peptides, the antigen was shown to contain five distinct lin...

Enlace original: https://cgspace.cgiar.org/handle/10568/28768

Investigación en Agricultura
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Nene, Vishvanath ,  Gobright, E.I. ,  Bishop, Richard P. ,  Morzaria, S.P. ,  Musoke, A.J. ,  [Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine] ,  Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralising epitopes: Implications for a vaccine

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