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Gastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus...


Benavides, M.V.Sonstegard, T.S.Kemp, Stephen J.Mugambi, J.M.M.Gibson, John P.Baker, R.L.Hanotte, Olivier H.Marshall, KarenTassell, C. van[Identification of novel loci associated with gastrointestinal parasite resistance in a red Maasai x Dorper backcross population]Identification of novel loci associated with gastrointestinal parasite resistance in a red Maasai x Dorper backcross population

Red Maasai and Dorper sheep were evaluated for their resistance to gastro-intestinal (GI) nematode parasites (predominantly Haemonchus contortus), productivity and productive efficiency (assessed on a metabolizable energy basis) in experiments undertaken at the Kenyan coast (sub-humid environment...


Baker, R.L.Mugambi, J.M.M.Audho, James O.Carles, A.B.Thorpe, W.R.[Genotype by environment interactions for productivity and resistance to gastro-intestinal nematode parasites in Red Maasai and Dorper sheep]Genotype by environment interactions for productivity and resistance to gastro-intestinal nematode parasites in Red Maasai and Dorper sheep

Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...


Behnke, J.M.Iraqi, F.A.Mugambi, J.M.M.Clifford, S.Nagda, S.M.Wakelin, D.Kemp, Stephen J.Leyden, B.Gibson, John P.[High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice]High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice

Six first cross (F1) Red Maasai X Dorper rams were mated to both Red Maasai (R) and Dorper (D) ewes to produce 1342 double backcross progeny (672 3/4 D/1/4 R and 670 3/4 R/1/4 D lambs born alive). These six double backcross resource families are being used to identify quantitative trait loci con...


Mugambi, J.M.M.Audho, James O.Baker, R.L.[Evaluation of the phenotypic performance of a Red Maasai and Dorper double backcross resource population: Natural pasture challenge with gastro-intestinal nematode parasites]Evaluation of the phenotypic performance of a Red Maasai and Dorper double backcross resource population: Natural pasture challenge with gastro-intestinal nematode parasites

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...


Behnke, J.M.Mugambi, J.M.M.Clifford, S.Iraqi, F.A.Baker, R.L.Gibson, John P.Wakelin, D.[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project

Six F1 Dorper (D) x Red Maasai (R) rams were mated to both D and R ewes to produce backcross lambs. These six double backcross resource families are being analysed to identify quantitative trait loci that may be controlling resistance to gastro-intestinal (GI) nematode parasites, mainly Haemonchu...


Mugambi, J.M.M.Audho, James O.Njomo, S.Baker, R.L.[Evaluation of the phenotypic performance of a Red Maasai and Dorper double backcross resource population: Indoor trickle challenge with Haemonchus contortus]Evaluation of the phenotypic performance of a Red Maasai and Dorper double backcross resource population: Indoor trickle challenge with Haemonchus contortus

A genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F1 rams. This design provided an opportunity to map potentially unique genetic variation a...


Silva, M.V.B.Sonstegard, T.S.Hanotte, Olivier H.Mugambi, J.M.M.García, J.F.Nagda, S.M.Gibson, John P.Iraqi, F.A.McClintock, A.E.Kemp, Stephen J.Boettcher, P.J.Malek, M.Tassell, C.P. vanBaker, R.L.[Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep]Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep

Disease resistance/tolerance, productivity and efficiency of Red Massai and Dorper sheep evaluated in experiments at the Kenya coast (humid environment) and the Kenya highlands (Semi-arid environment). There were important breed by location interactions for LWT, mortality rates and reproduction r...


Baker, R.L.Mugambi, J.M.M.Audho, James O.Carles, A.B.Thorpe, W.R.[Comparison of Red Maasai and Dorper sheep for resistance to gastro-intestinal nematode parasites productivity and efficiency in a humid and a semi-arid environment in Kenya]Comparison of Red Maasai and Dorper sheep for resistance to gastro-intestinal nematode parasites productivity and efficiency in a humid and a semi-arid environment in Kenya

Red Maasai [Masai] and Dorper sheep were evaluated for their resistance to gastrointestinal nematode parasites (predominantly Haemonchus contortus), productivity and efficiency in experiments undertaken at the Kenyan coast (humid environment) and the Kenya highlands (semiarid environment). It was...


Baker, R.L.Mugambi, J.M.M.Audho, James O.Carles, A.B.Thorpe, W.R.[Comparison of Red Maasai and Dorper sheep for resistance to gastro-intestinal nematode parasites: Productivity and efficiency in a humid and a semi-arid environment in Kenya]Comparison of Red Maasai and Dorper sheep for resistance to gastro-intestinal nematode parasites: Productivity and efficiency in a humid and a semi-arid environment in Kenya

A genome-wide scan was performed to detect quantitative trait loci (QTL) for resistance to the gastrointestinal nematode Haemonchus contortus in a double backcross population of Red Maasai and Dorper sheep. The mapping population comprised six sire families, with 1026 lambs in total. The lambs we...


Marshall, KarenMugambi, J.M.M.Nagda, S.M.Sonstegard, T.S.Tassell, C.P. vanBaker, R.L.Gibson, John P.[Quantitative trait loci for resistance to Haemonchus contortus artificial challenge in Red Maasai and Dorper sheep of East Africa]Quantitative trait loci for resistance to Haemonchus contortus artificial challenge in Red Maasai and Dorper sheep of East Africa

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