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Bett, Bernard K.Irungu, P.Nyamwaro, Sospeter S.Murilla, G.Kitala, P.Gathuma, G.Vale, G.Hargrove, J.Randolph, Thomas F.McDermott, John J.[Evaluation of the effectiveness of a synthetic tsetse-repellent technology for control of bovine trypanosomosis in Kenya]Evaluation of the effectiveness of a synthetic tsetse-repellent technology for control of bovine trypanosomosis in Kenya

In an on-farm trial conducted amongst the Maasai pastoralists in Nkuruman and Nkineji areas of Kenya between April 2004 and August 2005 designed to evaluate the effectiveness of a synthetic tsetse repellent technology, we assessed the relationship between tsetse challenge and trypanosomosis incid...


Bett, Bernard K.Irungu, P.Nyamwaro, Sospeter S.Murilla, G.Kitala, P.Gathuma, J.Randolph, Thomas F.McDermott, John J.[Estimation of tsetse challenge and its relationship with trypanosomosis incidence in cattle kept under pastoral production systems in Kenya]Estimation of tsetse challenge and its relationship with trypanosomosis incidence in cattle kept under pastoral production systems in Kenya

Testing of trypanocidal drug sensitivity in stabilates of pathogenic trypanosomes derived from cattle continues to be problematic, in spite of Development of in vitro techniques, since these are generally complicated and costly for the resources available in developing country laboratories. Furth...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice]A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice
Irungu, P.Bett, Bernard K.Mbogoh, S.G.Randolph, Thomas F.Nyamwaro, Sospeter S.Murilla, G.[Determinants of cattle market price volatility in Maasailand: a GARCH-M application]Determinants of cattle market price volatility in Maasailand: a GARCH-M application

Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...


Eisler, M.C.Brandt, J.Bauer, B.Clausen, P.H.Delespaux, V.Holmes, P.H.Ilemobade, A.Machila, N.Mbwambo, H.McDermott, John J.Mehlitz, D.Murilla, G.Ndung'u, J.M.Peregrine, A.S.Sidibe, I.Sinyangwe, L.Geerts, S.[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle

Two enzyme-linked immunosorbent assays (ELISA) for the determination of homidium in serum of treated cattle have been developed and evaluated. One is a direct competition (Assay 1) and the other an indirect competition assay (Assay 2). Both assays are highly sensitive with a limit of detection of...


Murilla, G.Eisler, M.C.Peregrine, A.S.Ndung'u, J.M.Holmes, P.H.[Development and evaluation of an enzyme-linked immunosorbent assay (ELISA) for the determination of the trypanocidal drug homidium in serum of treated cattle]Development and evaluation of an enzyme-linked immunosorbent assay (ELISA) for the determination of the trypanocidal drug homidium in serum of treated cattle
Bett, Bernard K.Irungu, P.Andoke, J.Nyamwaro, Sospeter S.Murilla, G.Saini, R.Hassanali, A.Olet, P.Kitala, P.Gathuma, G.Hargrove, J.Randolph, Thomas F.McDermott, John J.[Evaluation of a synthetic Tsetse-repellent developed for control of cattle trypanosomosis in Kenya]Evaluation of a synthetic Tsetse-repellent developed for control of cattle trypanosomosis in Kenya

Pharmacokinetic studies on the trypanocidal drug homidium bromide using a competitive enzyme immunoassay (detection limit 0.1 ng/mL) are reported for non-infected Friesian and Boran steers following treatment with homidium bromide at a dose of 1.0 mg/kg b.w. Following intravenous (i.v.) treatment...


Murilla, G.Holmes, P.H.Peregrine, A.S.Eisler, M.C.Ndung'u, J.M.[Some pharmacokinetic parameters of the trypanocidal drug homidium bromide in Friesian and Boran steers using an enzyme-linked immunosorbent assay (ELISA)]Some pharmacokinetic parameters of the trypanocidal drug homidium bromide in Friesian and Boran steers using an enzyme-linked immunosorbent assay (ELISA)

Control of trypanosomosis in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T. vivax in ...


Murilla, G.Peregrine, A.S.Holmes, P.H.Eisler, M.C.Ndung'u, J.M.[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle

Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...


Eisler, M.C.McDermott, John J.Mdachi, R.Murilla, G.Sinyangwe, L.Mubanga, J.Machila, N.Mbwambo, H.Coleman, P.G.Clausen, P.H.Bauer, B.Sidibe, I.Geerts, S.Holmes, P.H.Peregrine, A.S.[Rapid method for the assessment of trypanocidal drug resistance in the field]Rapid method for the assessment of trypanocidal drug resistance in the field

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