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Contagious bovine pleuropneumonia (CBPP) is a lung disease caused by the bacterial pathogen Mycoplasma mycoides ssp. mycoides small colony type (MmmSC). It has been spreading due to a number of factors including poor vaccine efficacy and poor sensitivity of current diagnostic tests. The purpose o...


Jores, JoergNkando, I.Sterner-Kock, AnjaHaider, W.Poole, Elizabeth J.Unger, H.Muriuki, C.Wesonga, H.O.Taracha, E.L.N.[Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type]Assessment of in vitro interferon-gamma responses from peripheral blood mononuclear cells of cattle infected with Mycoplasma mycoides ssp. mycoides small colony type

Mycoplasma mycoides subsp. capri (Mmc) and subsp. mycoides (Mmm) are important ruminant pathogens worldwide causing diseases such as pleuropneumonia, mastitis and septicaemia. They express galactofuranose residues on their surface, but their role in pathogenesis has not yet been determined. The M...


Schieck, Elise G.Lartigue, C.Frey, J.Vozza, N.Hegermann, J.Miller, R.A.Valguarnera, E.Muriuki, C.Meens, J.Nene, VishvanathNaessens, JanWeber, J.Lowary, T.L.Vashee, S.Feldman, M.F.Jores, Joerg[Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance]Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance
Muriuki, C.Bush, S.J.Salavati, M.McCulloch, M.E.B.Lisowski, Z.M.Agaba, MorrisDjikeng, AppolinaireHume, D.A.Clark, E.L.[A mini-atlas of gene expression for the domestic goat (Capra hircus)]A mini-atlas of gene expression for the domestic goat (Capra hircus)

African trypanosomes are important pathogens of both humans and livestock. We investigated the association of cytokine responses with disease susceptibility in Trypanosoma congolense-infected cattle. Changes in interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-12 p40, tumor necrosis factor-alph...


Mertens, B.Taylor, K.Muriuki, C.Rocchi, M.[Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4]Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4

The cDNA coding for the soluble form of bovine stem cell factor (boSCF-Ala-105) was cloned and recombinant protein was produced in bacteria as a histidine tagged-protein. The protein was purified from the inclusion bodies in one step by metal chelation chromatography under denaturing conditions. ...


Mertens, B.Muriuki, C.Muiya, P.Andrianarivo, A.Mwangi, S.Logan-Henfrey, L.L.[Bovine stem cell factor: Production of a biologically active protein and mRNA analysis in cattle infected with Trypanosoma congolense]Bovine stem cell factor: Production of a biologically active protein and mRNA analysis in cattle infected with Trypanosoma congolense

According to studies in human and mouse species it is apparent that both CD40 ligand and tumor necrosis factor alpha (TNF alpha) are members of a novel family of cytokines, referred to as the TNF - superfamily. This article reports the cloning of the cattle CD40 lignad and cattle TNF alpha, and s...


Mertens, B.Muriuki, C.Gaidulis, L.[Cloning of two members of the TNF - superfamily in cattle: CD40 ligand and tumor necrosis factor alpha]Cloning of two members of the TNF - superfamily in cattle: CD40 ligand and tumor necrosis factor alpha

Camels are the most valuable livestock species in the Horn of Africa and play a pivotal role in the nutritional sustainability for millions of people. Their health status is therefore of utmost importance for the people living in this region. Streptococcus agalactiae, a Group B Streptococcus (GBS...


Fischer, A.Liljander, Anne M.Kaspar, H.Muriuki, C.Fuxelius, H.H.Bongcam-Rudloff, E.Villiers, Etienne P. deHuber, C.A.Frey, J.Daubenberger, C.A.Bishop, Richard P.Younan, M.Jores, Joerg[Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element]Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element

The ‘Mycoplasma mycoides cluster’ comprises the ruminant pathogens Mycoplasma mycoides subsp. mycoides the causative agent of contagious bovine pleuropneumonia (CBPP), Mycoplasma capricolum subsp. capripneumoniae the agent of contagious caprine pleuropneumonia (CCPP), Mycoplasma capricolum subsp....


Fischer, A.Shapiro, Barry I.Muriuki, C.Heller, M.Schnee, C.Bongcam-Rudloff, E.Frey, J.Jores, Joerg[The origin of the Mycoplasma mycoides cluster coincides with domestication of ruminants]The origin of the Mycoplasma mycoides cluster coincides with domestication of ruminants

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated by CD8 T cells. Six antigens targeted by CD8 T cells from T. parva-immune cattle of different major histocompatibility complex (MHC) genotypes have been identified, raising the prospect of d...


Graham, S.P.Pelle, RogerYamage, M.Mwangi, D.M.Honda, Y.Mwakubambanya, R.S.Villiers, Etienne P. deAbuya, E.Awino, EliasGachanja, J.Mbwika, F.Muthiani, A.M.Muriuki, C.Nyanjui, J.K.[Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva]Characterization of the fine specificity of Bovine CD8 T-Cell responses to defined antigens from the protozoan parasite Theileria parva

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