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Cyclophilin A from the bovine parasite Trypanosoma brucei brucei has been cloned, expressed in Escherichia coli, purified and crystallized in the presence of cyclosporin A using ammonium sulfate as a precipitant. The crystals belong to the orthorhombic crystal system with unit-cell dimensions of ...


Dao-Thi, M.H.Transue, T.R.Pelle, RogerMurphy, N.B.Poortmans, F.Steyaert, J.[Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei]Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei
Waitumbi, J.N.Murphy, N.B.[Inter- and intra-species differentiation of trypanosomes by genomic fingerprinting with arbitrary primers]Inter- and intra-species differentiation of trypanosomes by genomic fingerprinting with arbitrary primers

The glycosome, a microbody organelle found only in kinetoplastid protozoa, compartmentalizes the first six enzymes of glycolysis. In order to better understand the regulation and targeting of glycolytic enzymes in trypanosomes. We have cloned and analyzed the three genes within the complex is sim...


Parker, H.L.Hill, T.Alexander, K.Murphy, N.B.Fish, W.R.Parsons, M.[Three genes and two isozymes: Gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense]Three genes and two isozymes: Gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense
Leegwater, P.A.J.Strating, M.Murphy, N.B.Kooy, R.F.Vliet, P.C. van derOverdulve, J.P.[The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame]The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame
Waitumbi, J.N.Murphy, N.B.Peregrine, A.S.[Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya]Genotype and drug-resistance phenotype of Trypanosoma evansi originating from camels in Northern Kenya
Murphy, N.B.Muthiani, M.Peregrine, A.S.[Use of an in vivo system to determine the G418 resistance phenotype of bloodstream-form Trypanosoma brucei brucei transfectants]Use of an in vivo system to determine the G418 resistance phenotype of bloodstream-form Trypanosoma brucei brucei transfectants
Ndoutamia, G.Moloo, S.K.Murphy, N.B.Peregrine, A.S.[Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense]Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense
Welburn, S.C.Murphy, N.B.[Prohibitin proto-oncogene and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated forms]Prohibitin proto-oncogene and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated forms
Preer, J.Watanabe, Y.Miceli, C.Murphy, N.B.[Protozoan genes: Their structure, products and regulation of expression]Protozoan genes: Their structure, products and regulation of expression

Members of the genus Trypanosoma, within the order Kinetoplastida, are unicellular parasitic organisms which are a major threat to human health and livestock productivity in large areas of the developing world. Despite their relatively small genome size, these primitive organisms undergo complex ...


Murphy, N.B.Pelle, Roger[Rapid identification of differentially expressed genes in trypanosomes]Rapid identification of differentially expressed genes in trypanosomes

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