Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...
Mamman, M.
,
Williams, D.J.L.
,
Murphy, N.B.
,
Peregrine, A.S.
,
[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]
,
Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense
The frequency of trypanosomes resistant to diminazene aceturate at a dose of 26 mg/kg of bwt was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene aceturate at the same dosage. At inoculum sizes of 102,...
Mamman, M.
,
Gettinby, N.B.
,
Murphy, N.B.
,
Kemei, S.
,
Peregrine, A.S.
,
[Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate]
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Frequency of diminazene - resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene aceturate
Peregrine, A.S.
,
Knowles, G.
,
Ibitayo, A.I.
,
Scott, J.R.
,
Moloo, S.K.
,
Murphy, N.B.
,
[Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense]
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Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense
Mamman, M.
,
Gettinby, G.
,
Murphy, N.B.
,
Kemei, S.
,
Peregrine, A.S.
,
[Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene]
,
Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene
A study was carried out to determine whether a drug-resistant trypanosome population could influence the survival of a drug-sensitive population in mixed infections in goats. To identify both populations during the course of a mixed infection, a system for distinguishing them was developed; using...
Burudi, E.M.E.
,
Peregrine, A.S.
,
Majiwa, P.A.O.
,
Mbiuki, S.M.
,
Murphy, N.B.
,
[Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats]
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Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats
The glycosome, a microbody organelle found only in kinetoplastid protozoa, compartmentalizes the first six enzymes of glycolysis. In order to better understand the regulation and targeting of glycolytic enzymes in trypanosomes. We have cloned and analyzed the three genes within the complex is sim...
Parker, H.L.
,
Hill, T.
,
Alexander, K.
,
Murphy, N.B.
,
Fish, W.R.
,
Parsons, M.
,
[Three genes and two isozymes: Gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense]
,
Three genes and two isozymes: Gene conversion and the compartmentalization and expression of the phosphoglycerate kinases of Trypanosoma (Nannomonas) congolense
Ndoutamia, G.
,
Moloo, S.K.
,
Murphy, N.B.
,
Peregrine, A.S.
,
[Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense]
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Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense
Chemotherapy is the single most important strategy for the control of trypanosomosis in African livestock. Trypanocidal drug resistance is a growing problem across much of sub-Saharan Africa and increasingly recognised as a major threat to livestock production. It is therefore of pressing importa...
Coleman, P.G.
,
Eisler, M.C.
,
McDermott, John J.
,
Murphy, N.B.
,
Majiwa, P.A.O.
,
Peregrine, A.S.
,
[Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense]
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Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense