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A Trypanosoma brucei brucei DNA repeat sequence termed NlaIII repeat (NR) was originally isolated from a multidrug-resistant field isolate CP547 [Jamnadass, R., 1995. Identification and characterisation of an extrachromosomal element from a multidrug-resistant isolate of T. brucei brucei, Ph.D. t...


Jamnadass, Ramni H.Pelle, RogerPandit, P.Ricard, B.Murphy, N.B.[Trypanosoma brucei: Composition, organisation, plasticity, and differential transcription of NlaIII repeat elements in drug-resistant and sensitive isolates]Trypanosoma brucei: Composition, organisation, plasticity, and differential transcription of NlaIII repeat elements in drug-resistant and sensitive isolates

The review discusses the current field status of human and bovine trypanosomiases, and focuses on the molecular basis of innate and acquired control of African trypanosomes in people, cattle and Cape buffalo


Black, S.J.Seed, J.R.Murphy, N.B.[Innate and acquired resistance to African trypanosomiasis]Innate and acquired resistance to African trypanosomiasis

The QM protein has been reported to have roles in both tumour suppression and transcription factor regulation in vertebrate cells, and in ribosome stability in both yeast and mammals. The present study isolated the QM gene of Trypanosoma brucei and determined its sequence. Alignment with QM seque...


Lillico, S.G.Mottram, J.C.Murphy, N.B.Welburn, S.C.[Characterisation of the QM gene of Trypanosoma brucei]Characterisation of the QM gene of Trypanosoma brucei
Alexandre, S.Guyaux, M.Murphy, N.B.Coquelet, H.Pays, A.Steinert, M.Pays, E.[Putative genes of a variant-specific antigen gene transcription unit in Trypanosoma brucei]Putative genes of a variant-specific antigen gene transcription unit in Trypanosoma brucei

Procyclic Trypanosoma brucei rhodesiense have a cell death mechanism which can be activated by an external signal, the lectin ConA, in vitro. ConA has been shown to cause profound changes in cellular morphology and induce fragmentation of nuclear DNA in T.b. rhodesiense which are characteristic o...


Murphy, N.B.Welburn, S.C.[Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs]Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs

Cyclophilin A from the bovine parasite Trypanosoma brucei brucei has been cloned, expressed in Escherichia coli, purified and crystallized in the presence of cyclosporin A using ammonium sulfate as a precipitant. The crystals belong to the orthorhombic crystal system with unit-cell dimensions of ...


Dao-Thi, M.H.Transue, T.R.Pelle, RogerMurphy, N.B.Poortmans, F.Steyaert, J.[Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei]Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei
Leegwater, P.A.J.Strating, M.Murphy, N.B.Kooy, R.F.Vliet, P.C. van derOverdulve, J.P.[The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame]The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame
Murphy, N.B.Muthiani, M.Peregrine, A.S.[Use of an in vivo system to determine the G418 resistance phenotype of bloodstream-form Trypanosoma brucei brucei transfectants]Use of an in vivo system to determine the G418 resistance phenotype of bloodstream-form Trypanosoma brucei brucei transfectants

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