Two novel baculovirus-derived recombinant Theileria parva p67 constructs were tested for their vaccine potential against East Coast fever. Boran calves were immunized with a his-GFP-p67 fusion protein (GFP:p67DeltaSS) or with GP64:p67C, a protein fusion between a C-terminal domain of p67 and th...
Shaw, M.K.
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Tilney, L.G.
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Musoke, A.J.
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[The entry of Theileria parva sporozoites into bovine lymphocytes: Evidence for MHC class I involvement]
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The entry of Theileria parva sporozoites into bovine lymphocytes: Evidence for MHC class I involvement
East Coast fever (ECF) in cattle is caused by the tick-borne protozoan parasite Theileria parva. The major sporozoite surface antigen of T. parva (p67) is an important candidate for inclusion in a subunit vaccine. Recently, we reported the expression and production of different parts of p67 as f...
Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...
Musoke, A.J.
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Rowlands, G.J.
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Nene, Vishvanath
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Nyanjui, J.
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Katende, J.
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Spooner, P.R.
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Mwaura, S.
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Odongo, D.
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Nkonge, C.
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Mbogo, S.
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Bishop, Richard P.
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Morzaria, S.P.
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[Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge]
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Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge
Improvement of the livestock industry in many developing countries has been severely constrained by tick-borne diseases. The major protozoan pathogens responsible for these diseases in cattle are Theileria parva and B. annulata and Babesia bigemina and B. bovis. East Coast fever is of great econo...
Musoke, A.J.
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Morzaria, S.P.
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Nene, Vishvanath
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[Subunit vaccines for the control of Theileria parva]
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Subunit vaccines for the control of Theileria parva
Ole-MoiYoi, O.K.
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Nayar, A.
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Iams, K.P.
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Musoke, A.J.
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Yilma, T.
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[Molecular aspects of Theileria parva and approaches to vaccine development for animals]
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Molecular aspects of Theileria parva and approaches to vaccine development for animals
Rurangirwa, F.R.
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Musoke, A.J.
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Nantulya, V.M.
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Nkonge, C.
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Njuguna, L.
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Mushi, E.Z.
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Karstad, L.
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Grootenhuis, J.G.
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[Immune effector mechanisms involved in the control of parasitaemia in Trypanosoma brucei-infected wildebeest (Connochaetes taurinus)]
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Immune effector mechanisms involved in the control of parasitaemia in Trypanosoma brucei-infected wildebeest (Connochaetes taurinus)
Nantulya, V.M.
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Musoke, A.J.
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Rurangirwa, F.R.
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Moloo, S.K.
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[Resistance of cattle to tsetse-transmitted challenge with Trypanosoma brucei or Trypanosoma congolense after spontaneous recovery from syringe-passaged infections]
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Resistance of cattle to tsetse-transmitted challenge with Trypanosoma brucei or Trypanosoma congolense after spontaneous recovery from syringe-passaged infections
The polymorphic immunodominant molecule (PIM) of Theileria parva is expressed by the schizont and sporozoite stages of the parasite. We have recently cloned the cDNA encoding the PIM antigen from two stocks of the parasite: the cattle-derived T. parva (Muguga) stock and a buffalo-derived stock. T...
Toye, Philip G.
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Nyanjui, J.
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Goddeeris, B.M.
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Musoke, A.J.
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[Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva]
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Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva