The Development of a recombinant Theileria parva vaccine is discussed under the following headings: mechanisms of protection against ECF [East Coast fever]; cloning and expression of p67; immunization and challenge of cattle; interpretation of immunization and challenge data.
Musoke, A.J.
,
McKeever, Declan J.
,
Morzaria, S.P.
,
Nkonge, C.
,
Nene, Vishvanath
,
[A recombinant vaccine for Theileria parva]
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A recombinant vaccine for Theileria parva
The major sporozoite surface antigen of Theileria annulata (SPAG-1) is a candidate for inclusion in a subunit vaccine. In this paper we summarize the results of 4 vaccination experiments using recombinant SPAG-1 expressed in different systems and presented in different adjuvants. The antigen has ...
Boulter, N.
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Brown, D.
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Wilkie, G.
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Williamson, S.
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Kirvar, E.
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Knight, P.
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Glass, E.
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Campbell, J.
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Morzaria, S.P.
,
Nene, Vishvanath
,
Musoke, A.J.
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Oliveria, C. de
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Gubbels, M.J.
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Jongejan, F.
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Hall, R.
,
[Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems]
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Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems
Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...
Musoke, A.J.
,
McKeever, Declan J.
,
Morzaria, S.P.
,
Nkonge, C.
,
Nene, Vishvanath
,
[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]
,
Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen
Bovine theileriosis caused by Theileria parva continues to be a major economic problem in many parts of Eastern, Southern, and Central Africa. Due to the unsustainable nature or the present control method-using toxic acaricides to kill ticks - alternative control methods are being sought. Live va...