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Previous data showed that six out of a group of nine cattle inoculated with NS1-p67, a recombinant form of a 67-KDa Theileria parva sporozoite surface protein, were immune to East Coast fever. This bacterialy expressed antigen encoded all 709 amino acid residues of p67 fused to the C-terminal end...


Nene, VishvanathInumaru, S.McKeever, Declan J.Morzaria, S.P.Shaw, M.Musoke, A.J.[Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle]Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle

Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an i...


Ballingall, K.T.Luyai, A.Rowlands, G.J.Sales, J.Musoke, A.J.Morzaria, S.P.McKeever, Declan J.[Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen]Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen

To define Babesia bigemina-specific antigens on the surface of infected erythrocytes, monoclonal antibodies (MAbs) were identified by live-cell immunofluorescence. As determined by live-cell immunofluorescence, two MAbs made to the Mexico strain reacted with the Mexico strain and three Kenya stra...


Shompole, S.Perryman, L.E.Rurangirwa, F.R.McElwain, T.F.Jasmer, D.P.Musoke, A.J.Wells, C.W.McGuire, T.C.[Monoclonal antibody to a conserved epitope on proteins encoded by Babesia bigemina and present on the surface of intact infected erythrocytes]Monoclonal antibody to a conserved epitope on proteins encoded by Babesia bigemina and present on the surface of intact infected erythrocytes

The p67 sporozoite antigen of Theileria parva has been fused to the C-terminal secretion signal of Escherichia coli hemolysin and expressed in secreted form by attenuated Salmonella dublin areA strain SL5631. The recombinant p67 antigen was detected in the supernatant of transformed bacterial cul...


Gentschev, I.Glaser, I.Goebel, W.McKeever, Declan J.Musoke, A.J.Heussler, V.T.[Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: Secretion of the product enhances specific antibody responses in cattle]Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: Secretion of the product enhances specific antibody responses in cattle
Nantulya, V.M.Musoke, A.J.Moloo, S.K.[Apparent exhaustion of the variable antigen repertoires of Trypanosoma vivax in infected cattle]Apparent exhaustion of the variable antigen repertoires of Trypanosoma vivax in infected cattle

Heterologous priming-boosting vaccination regimens involving priming with plasmid DNA antigen constructs and inoculating (boosting) with the same recombinant antigen expressed in replication-attenuated poxviruses have recently been demonstrated to induce immunity, based on CD4(+)- and CD8(+)-T-c...


Taracha, E.L.N.Bishop, Richard P.Musoke, A.J.Hill, A.V.S.Gilbert, S.C.[Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses]Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses
Nantulya, V.M.Musoke, A.J.Rurangirwa, F.R.Barbet, A.F.Ngaira, J.M.Katende, J.M.[Immune depression in African trypanosomiasis. The role of antigenic competition]Immune depression in African trypanosomiasis. The role of antigenic competition

Immunity to Theileria parva infection in cattle is often parasite stock specific. The antigenic diversity which is expressed at the schizont stage of the parasite together with a wild reservoir of the organism in buffalo has complicated the development of effective disease control by immunization...


Nene, VishvanathMusoke, A.J.Gobright, E.I.Morzaria, S.P.[Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles]Conservation of the sporozoite p67 vaccine antigen in cattle-derived Theileria parva stocks with different cross-immunity profiles
Nene, VishvanathIams, K.P.Musoke, A.J.[Molecular characterization of a Theileria parva surface sporozoite antigen]Molecular characterization of a Theileria parva surface sporozoite antigen

Discusses prospects for the Development of a vaccine against African trypanosomiasis & dissemination of genetically resistant breeds of livestock into tsetse-infected areas of the continent; reviewing the various approaches being pursued for vaccine Development, viz. induction of immunity by use ...


Nantulya, V.M.Musoke, A.J.[Prospects for the development of an effective immunological method for the control of African trypanosomiasis]Prospects for the development of an effective immunological method for the control of African trypanosomiasis

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