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Pinder, M.Musoke, A.J.Morrison, W. IvanRoelants, G.E.[The bovine lymphoid system. 3. A monoclonal antibody specific for bovine cell surface and serum IgM]The bovine lymphoid system. 3. A monoclonal antibody specific for bovine cell surface and serum IgM

Previous data showed that six out of a group of nine cattle inoculated with NS1-p67, a recombinant form of a 67-KDa Theileria parva sporozoite surface protein, were immune to East Coast fever. This bacterialy expressed antigen encoded all 709 amino acid residues of p67 fused to the C-terminal end...


Nene, VishvanathInumaru, S.McKeever, Declan J.Morzaria, S.P.Shaw, M.Musoke, A.J.[Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle]Characterization of an insect cell-derived Theileria parva sporozoite vaccine antigen and immunogenicity in cattle

Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an i...


Ballingall, K.T.Luyai, A.Rowlands, G.J.Sales, J.Musoke, A.J.Morzaria, S.P.McKeever, Declan J.[Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen]Bovine leukocyte antigen major histocompatibility complex class II DRB3*2703 and DRB3*1501 alleles are associated with variation in levels of protection against Theileria parva challenge following immunization with the sporozoite p67 antigen

To define Babesia bigemina-specific antigens on the surface of infected erythrocytes, monoclonal antibodies (MAbs) were identified by live-cell immunofluorescence. As determined by live-cell immunofluorescence, two MAbs made to the Mexico strain reacted with the Mexico strain and three Kenya stra...


Shompole, S.Perryman, L.E.Rurangirwa, F.R.McElwain, T.F.Jasmer, D.P.Musoke, A.J.Wells, C.W.McGuire, T.C.[Monoclonal antibody to a conserved epitope on proteins encoded by Babesia bigemina and present on the surface of intact infected erythrocytes]Monoclonal antibody to a conserved epitope on proteins encoded by Babesia bigemina and present on the surface of intact infected erythrocytes

The p67 sporozoite antigen of Theileria parva has been fused to the C-terminal secretion signal of Escherichia coli hemolysin and expressed in secreted form by attenuated Salmonella dublin areA strain SL5631. The recombinant p67 antigen was detected in the supernatant of transformed bacterial cul...


Gentschev, I.Glaser, I.Goebel, W.McKeever, Declan J.Musoke, A.J.Heussler, V.T.[Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: Secretion of the product enhances specific antibody responses in cattle]Delivery of the p67 sporozoite antigen of Theileria parva by using recombinant Salmonella dublin: Secretion of the product enhances specific antibody responses in cattle
Barbet, A.F.Musoke, A.J.Vervoort, T.Meirvenne, N. vanMpimbaza, G.W.N.Magnus, E.[Cross-reacting antigenic determinants in variable surface glycoproteins from isotypic African trypanosomes]Cross-reacting antigenic determinants in variable surface glycoproteins from isotypic African trypanosomes

Commercial vaccines based on recombinant forms of the Bm86 tick gut antigen are used to control the southern cattle tick, Rhipicephalus microplus, a 1-host species, in Australia and Latin America. We describe herein sequence polymorphism in genes encoding Ra86 homologues of Bm86 in the brown ear ...


Kamau, L.M.Skilton, Robert A.Githaka, Naftaly W.Kiara, Henry K.Kabiru, E.Shah, TushaarMusoke, A.J.Bishop, Richard P.[Extensive polymorphism of Ra86 genes in field populations of Rhipicephalus appendiculatus from Kenya]Extensive polymorphism of Ra86 genes in field populations of Rhipicephalus appendiculatus from Kenya

Theileria parva is a tick-transmitted apicomplexan parasite that infects cattle and African buffalo. In cattle, it causes a fatal lymphoproliferative disease called East Coast fever. The polymorphic immunodominant molecule (PIM) is expressed by two stages of the parasite: the sporozoite, which is...


Toye, Philip G.Musoke, A.J.Naessens, Jan[Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes]Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes
Masake, R.A.Nantulya, V.M.Akol, G.W.O.Musoke, A.J.[Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and Trypanosoma brucei brucei infections]Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and Trypanosoma brucei brucei infections

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