Vaccines based on recombinant Bm86 gut antigen from Boophilus microplus are a useful component of integrated control strategies against B. microplus infestations of cattle. The capacity of such vaccines to control heterologous infestations by two African tick species was investigated. The mean we...
Odongo, D.
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Kamau, L.
,
Skilton, Robert A.
,
Mwaura, S.
,
Nitsch, C.
,
Musoke, A.J.
,
Taracha, E.A.
,
Daubenberger, C.A.
,
Bishop, Richard P.
,
[Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus]
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Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus
Background
The ixodid tick Rhipicephalus appendiculatus transmits the apicomplexan protozoan parasite Theileria parva,which causes East coast fever (ECF), the most economically important cattle disease in eastern and southern Africa. Recent analysis of micro- and minisatellite markers showed an a...
Kanduma, E.G.
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Mwacharo, Joram M.
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Githaka, Naftaly W.
,
Kinyanjui, P.W.
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Njuguna, J.
,
Kamau, L.M.
,
Kariuki, E.
,
Mwaura, S.
,
Skilton, Robert A.
,
Bishop, Richard P.
,
[Analyses of mitochondrial genes reveal two sympatric but genetically divergent lineages of Rhipicephalus appendiculatus in Kenya]
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Analyses of mitochondrial genes reveal two sympatric but genetically divergent lineages of Rhipicephalus appendiculatus in Kenya
The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...
Patel, Ekta
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Lubembe, D.M.
,
Gachanja, J.
,
Mwaura, S.
,
Spooner, P.R.
,
Toye, Philip G.
,
[Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity]
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Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity
Commercial vaccines based on the tick gut protein Bm86 have been successful in controlling the one-host tick Rhipicephalus (Boophilus) microplus and provide heterologous protection against certain other non-target ixodid tick species. This cross protection, however, does not extend to the three-h...
Olds, Cassandra L.
,
Mwaura, S.
,
Crowder, D.
,
Odongo, D.
,
Oers, M.M. van
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Owen, J.
,
Bishop, Richard P.
,
Daubenberger, C.A.
,
[Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting]
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Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting
Integrative management of wildlife and livestock requires a clear understanding of the diseases transmitted between the two populations. The tick-borne protozoan parasite Theileria parva causes two distinct diseases in cattle, East Coast fever and Corridor disease, following infection with parasi...
Sitt, T.
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Poole, Elizabeth J.
,
Ndambuki, Gideon M.
,
Mwaura, S.
,
Njoroge, T.
,
Omondi, G.P.
,
Mutinda, M.
,
Mathenge, J.
,
Prettejohn, G.
,
Morrison, W. Ivan
,
Toye, Philip G.
,
[Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva]
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Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva