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Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the ne...


Pérez Casal, J.Prysliak, T.Maina, T.Wang, Y.Townsend, H.Berverov, E.Nkando, I.Wesonga, H.O.Liljander, Anne M.Jores, JoergNaessens, JanGerdts, V.Potter, A.[Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia]Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia

Contagious bovine pleuropneumonia (CBPP) is a serious respiratory disease of cattle caused by Mycoplasma mycoides subsp. mycoides. Current vaccines against CBPP induce short-lived immunity and can cause severe postvaccine reactions. Previous studies have identified the N terminus of the transmemb...


Mulongo, M.Frey, J.Smith, K.Schnier, C.Wesonga, H.O.Naessens, JanMcKeever, Declan J.[Vaccination of cattle with the N terminus of LppQ of Mycoplasma mycoides subsp. mycoides results in type III immune complex disease upon experimental infection]Vaccination of cattle with the N terminus of LppQ of Mycoplasma mycoides subsp. mycoides results in type III immune complex disease upon experimental infection

Contagious Bovine Pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides, is widespread in sub-Saharan Africa. The current live vaccine T1/44 has limited efficacy and occasionally leads to severe side effects in the animals. A better understanding of the immune responses triggered ...


Sacchini, F.Luciani, M.Salini, R.Scacchia, M.Pini, A.Lelli, R.Naessens, JanPoole, Elizabeth J.Jores, Joerg[Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia]Plasma levels of TNF-α, IFN-γ, IL-4 and IL-10 during a course of experimental contagious bovine pleuropneumonia

Background: Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP), a respiratory disease of cattle, whereas the closely related Mycoplasma mycoides subsp. capri (Mmc) is a goat pathogen. Cyto-adherence is a crucial step in host colonization b...


Aye, R.Mwirigi, M.K.Frey, J.Pilo, P.Jores, JoergNaessens, Jan[Cyto-adherence of Mycoplasma mycoides subsp. mycoides to bovine lung epithelial cells]Cyto-adherence of Mycoplasma mycoides subsp. mycoides to bovine lung epithelial cells
Lutta, H.O.Mather, A.Maina, T.W.Odongo, D.Ndiwa, Nicholas N.Wesonga, H.O.Naessens, Jan[Preliminary findings of lipoprotein B in detecting cattle chronically infected with contagious bovine pleuropneumonia]Preliminary findings of lipoprotein B in detecting cattle chronically infected with contagious bovine pleuropneumonia
Naessens, JanHoward, C.J.[Monoclonal antibodies reacting with bovine B cells (BoWC3, BoWC4 and BoWC5)]Monoclonal antibodies reacting with bovine B cells (BoWC3, BoWC4 and BoWC5)

The current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides(Mmm). However, this method is not very efficient and often causes serious adverse reactions. Several studies have attempted to ind...


Mwirigi, M.Nkando, I.Aye, R.Soi, R.Ochanda, H.Berberov, E.Potter, A.Gerdts, V.Pérez Casal, J.Naessens, JanWesonga, H.O.[Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides]Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. Mycoides
Nthale, J.M.Naessens, Jan[Characterization of a late activation antigen defined by monoclonal antibodies of cluster BoWC8 (TC23)]Characterization of a late activation antigen defined by monoclonal antibodies of cluster BoWC8 (TC23)
Muiya, P.Logan-Henfrey, L.L.Naessens, Jan[Expression of antigens on haemopoietic progenitor cells in bovine bone marrow]Expression of antigens on haemopoietic progenitor cells in bovine bone marrow

Diagnosis and control of dourine is strongly based on serological evidence, but knowledge of the humoral response of horses during infection is limited. In this study we developed a chemiluminescent immunoblotting (cIB) assay to characterise the Trypanosoma equiperdum antigen pattern recognised b...


Luciani, M.Pancrazio, C. DiFebo, T. DiTittarelli, M.Vulpiani, M.P.Puglielli, M.O.Naessens, JanSacchini, F.[IgG antibodies from dourine infected horses identify a distinctive Trypanosoma equiperdum antigenic pattern of low molecular weight molecules]IgG antibodies from dourine infected horses identify a distinctive Trypanosoma equiperdum antigenic pattern of low molecular weight molecules

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