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Members of ‘Mycoplasma mycoides cluster’ are important ruminant pathogens in Africa. Diseases caused by these Mycoplasma negatively affect the agricultural sector especially in developing countries through losses in livestock productivity, mortality and international trade restrictions. There is ...


Kama-Kama, F.Midiwo, JacobNg'ang'a, J.Maina, N.Schieck, Elise G.Omosa, L.K.Osanjo, G.Naessens, Jan[Selected Ethno-medicinal plants from Kenya with in vitroactivity against major African livestock pathogens belonging to the “Mycoplasma mycoides cluster’]Selected Ethno-medicinal plants from Kenya with in vitroactivity against major African livestock pathogens belonging to the “Mycoplasma mycoides cluster’

Theileria parva is a tick-transmitted apicomplexan parasite that infects cattle and African buffalo. In cattle, it causes a fatal lymphoproliferative disease called East Coast fever. The polymorphic immunodominant molecule (PIM) is expressed by two stages of the parasite: the sporozoite, which is...


Toye, Philip G.Musoke, A.J.Naessens, Jan[Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes]Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes

It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exp...


Williams, D.J.L.Taylor, K.Newson, J.Gichuki, B.Naessens, Jan[The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance]The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance
Newson, J.Naessens, JanStagg, D.A.Black, S.J.[A cell surface antigen associated with Theileria parva lawrencei -infected bovine lymphoid cells]A cell surface antigen associated with Theileria parva lawrencei -infected bovine lymphoid cells
Grab, D.J.Shaw, M.K.Wells, C.W.Russo, D.C.W.Webster, P.Verjee, Y.Naessens, JanFish, W.R.[The transferrin receptor in African trypanosomes: Identification, partial characterization and subcellular localization]The transferrin receptor in African trypanosomes: Identification, partial characterization and subcellular localization

Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...


Kitani, H.Yagi, Y.Naessens, JanSekikawa, K.Iraqi, F.A.[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene]The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene
Williams, D.J.L.Naessens, JanScott, J.R.McOdimba, F.A.[Analysis of peripheral leucocyte populations in N'Dama and Boran cattle following a rechallenge infection with Trypanosoma congolense]Analysis of peripheral leucocyte populations in N'Dama and Boran cattle following a rechallenge infection with Trypanosoma congolense

A flow cytometric method using anti-parasite antibodies was developed to measure binding of theileria parva sporozoites to the target bovine lymphocyte membrane. Parasite-host cell interactions could be inhibited by monoclonal antibodies to bovine MHC class I and partially by one of two antibodie...


Syfrig, J.Wells, C.Daubenberger, C.A.Musoke, A.J.Naessens, Jan[Proteolytic cleavage of surface proteins enhances susceptibility of lymphocytes to invasion by Theileria parva sporozoites]Proteolytic cleavage of surface proteins enhances susceptibility of lymphocytes to invasion by Theileria parva sporozoites

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