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Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-alpha (TNF-alpha), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia...


Naessens, JanKitani, H.Nakamura, Y.Yagi, Y.Sekikawa, K.Iraqi, F.A.[TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
Naessens, JanWilliams, D.J.L.[Characterization and measurement of CD5+ B cells in normal and Trypanosoma congolense- infected cattle]Characterization and measurement of CD5+ B cells in normal and Trypanosoma congolense- infected cattle
Black, S.J.Sendashoga, Cyrie N.O'Brien, C.Borowy, N.K.Naessens, JanWebster, P.Murray, M.[Regulation of parasitaemia in mice infected with Trypanosoma brucei]Regulation of parasitaemia in mice infected with Trypanosoma brucei

Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...


Rathkolb, B.Noyes, H.A.Brass, A.Dark, P.Fuchs, H.Gailus-Durner, V.Gibson, John P.Angelis, M.H. deOgugo, M.Iraqi, F.A.Kemp, Stephen J.Naessens, JanPope, M.E.Wolf, E.Agaba, Morris[Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection]Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but tre...


Noyes, H.A.Alimohammadian, M.H.Agaba, MorrisBrass, A.Fuchs, H.Gailus-Durner, V.Hulme, H.Iraqi, F.A.Kemp, Stephen J.Rathkolb, B.Wolf, E.Angelis, M.H. deRoshandel, D.Naessens, Jan[Mechanisms controlling anaemia in Trypanosoma congolense infected mice]Mechanisms controlling anaemia in Trypanosoma congolense infected mice
Autor: Naessens, Jan

Although specific immunoglobulin (Ig) and B cell responses are suppressed during an infection, there is a general activation of the humoral component of the immune system in infections with African trypanosomes. The changes in the humoral immune systems during infections are summarised in this pa...


Naessens, Jan[CD5+ B lymphocytes in cattle infected with African trypanosomiasis]CD5+ B lymphocytes in cattle infected with African trypanosomiasis
Taylor, K.A.Gichuki, B.Lutje, V.Naessens, JanWilliams, D.J.L.[In vitro activation and detection of antibody-secreting cells from Trypanosoma congolense-infected cattle]In vitro activation and detection of antibody-secreting cells from Trypanosoma congolense-infected cattle
Martini, J.C. deMacHugh, Niall D.Naessens, JanTeale, A.J.[Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva]Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva
Williams, D.J.L.Taylor, K.A.Newson, J.Naessens, Jan[Specificity of serum antibodies derived from Trypanosoma congolense infected cattle]Specificity of serum antibodies derived from Trypanosoma congolense infected cattle
Flynn, J.N.McKeever, Declan J.Sileghem, M.R.Naessens, Jan[Modulation of the phenotype and function of bovine afferent lymph cells during infection with Trypanosoma congolense]Modulation of the phenotype and function of bovine afferent lymph cells during infection with Trypanosoma congolense

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