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The first visible response in livestock to the bite of a trypanosome-infected tsetse fly is the formation of a localized skin reaction, also known as a chancre. This is an inflammatory response in the skin associated with swelling and an influx of cells. It is thought to be associated with an a...


Naessens, JanMwangi, D.M.Buza, J.Moloo, S.K.[Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes]Local skin reaction (chancre) induced following inoculation of metacyclic trypanosomes in cattle by tsetse flies is dependent on CD4 T lymphocytes
Naessens, JanNewson, J.Bensaid, A.Teale, A.J.Magondu, J.Black, S.J.[De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle]De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle
Autor: Naessens, Jan

IgD, first demonstrated in humans, has been unequivocally shown to exist in primates and rodents. In addition to lgM a second unique membrane isotype, generally considered to be lgD, has been demonstrated in a number of other species, including dogs and chickens. Because of its assumed widespread...


Naessens, Jan[Surface lg on B lymphocytes from cattle and sheep]Surface lg on B lymphocytes from cattle and sheep
Naessens, Jan[Characterisation of lymphocyte populations in African buffalo (Syncerus caffer) and water buck (Kobus defassa) with workshop monoclonal antibodies]Characterisation of lymphocyte populations in African buffalo (Syncerus caffer) and water buck (Kobus defassa) with workshop monoclonal antibodies

Conditions were established to obtain depletion of T lymphocyte subsets in lymphoid tissues of calves by injection of mouse monoclonal antibodies to T cell antigens. Adverse reactions were avoided by injecting small quantities of antibody until target cells had disappeared from blood. Two differe...


Naessens, JanScheerlinck, J.P.Buysscher, E.V. deKennedy, D.Sileghem, M.R.[Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies]Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies
Naessens, JanWilliams, D.J.L.[Characterization and measurement of CD5+ B cells in normal and Trypanosoma congolense- infected cattle]Characterization and measurement of CD5+ B cells in normal and Trypanosoma congolense- infected cattle
Fritsch, G.Nelson, R.T.Muiya, P.Naessens, JanBlack, S.J.[Characterization of bovine haemopoietic progenitor cells using monoclonal antibodies and fluorocytometry]Characterization of bovine haemopoietic progenitor cells using monoclonal antibodies and fluorocytometry

East coast fever (ECF) is a major tick-borne disease caused by the apicomplexan parasite Theileria parva (1). ECF is an acute leukemia-like disease of cattle that is endemic in eastern, central and souther Africa, where it is responsible for significant mortality and losses in animal production. ...


Grab, D.J.Naessens, JanOle-MoiYoi, O.K.[Evidence for ADP-ribosylation and G protein in Theileria parva-transformed bovine lymphocytes]Evidence for ADP-ribosylation and G protein in Theileria parva-transformed bovine lymphocytes
Autor: Naessens, Jan

Although specific immunoglobulin (Ig) and B cell responses are suppressed during an infection, there is a general activation of the humoral component of the immune system in infections with African trypanosomes. The changes in the humoral immune systems during infections are summarised in this pa...


Naessens, Jan[CD5+ B lymphocytes in cattle infected with African trypanosomiasis]CD5+ B lymphocytes in cattle infected with African trypanosomiasis
Bensaid, A.M.Naessens, JanKemp, Stephen J.Black, S.J.Shapiro, S.Z.Teale, A.J.[An immunochemical analysis of class I (BoLA) molecules on the surface of bovine cells]An immunochemical analysis of class I (BoLA) molecules on the surface of bovine cells

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