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Tumor necrosis factor-α (TNF-α) plays a role in the host’s defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can influence paras...


Kitani, H.Yagi, Y.Naessens, JanSekikawa, K.Iraqi, F.A.[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene]The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene

Theileria parva is a tick-transmitted protozoan parasite that infects and transforms bovine lymphocytes. We have previously shown that Theileria parva Chitongo is an isolate with a lower virulence than that of T. parva Muguga. Lower virulence appeared to be correlated with a delayed onset of the ...


Tindih, H.S.Geysen, D.Goddeeris, B.M.Awino, EliasDobbelaere, D.A.E.Naessens, Jan[A Theileria parva isolate of low virulence infects a subpopulation of lymphocytes]A Theileria parva isolate of low virulence infects a subpopulation of lymphocytes
Autor: Naessens, Jan

Although specific immunoglobulin (Ig) and B cell responses are suppressed during an infection, there is a general activation of the humoral component of the immune system in infections with African trypanosomes. The changes in the humoral immune systems during infections are summarised in this pa...


Naessens, Jan[CD5+ B lymphocytes in cattle infected with African trypanosomiasis]CD5+ B lymphocytes in cattle infected with African trypanosomiasis
Martini, J.C. deMacHugh, Niall D.Naessens, JanTeale, A.J.[Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva]Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva

Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP), a devastating respiratory disease mainly affecting cattle in sub-Saharan Africa. The current vaccines are based on live-attenuated Mmmstrains and present problems with temperature stabili...


Nkando, I.Pérez Casal, J.Mwirigi, M.Prysliak, T.Townsend, H.Berberov, E.Kuria, J.Mugambi, J.Soi, R.Liljander, Anne M.Jores, JoergGerdts, V.Potter, A.Naessens, JanWesonga, H.O.[Recombinant Mycoplasma mycoides proteins elicit protective immune responses against contagious bovine pleuropneumonia]Recombinant Mycoplasma mycoides proteins elicit protective immune responses against contagious bovine pleuropneumonia

Members of ‘Mycoplasma mycoides cluster’ are important ruminant pathogens in Africa. Diseases caused by these Mycoplasma negatively affect the agricultural sector especially in developing countries through losses in livestock productivity, mortality and international trade restrictions. There is ...


Kama-Kama, F.Midiwo, JacobNg'ang'a, J.Maina, N.Schieck, Elise G.Omosa, L.K.Osanjo, G.Naessens, Jan[Selected Ethno-medicinal plants from Kenya with in vitroactivity against major African livestock pathogens belonging to the “Mycoplasma mycoides cluster’]Selected Ethno-medicinal plants from Kenya with in vitroactivity against major African livestock pathogens belonging to the “Mycoplasma mycoides cluster’

Theileria parva is a tick-transmitted apicomplexan parasite that infects cattle and African buffalo. In cattle, it causes a fatal lymphoproliferative disease called East Coast fever. The polymorphic immunodominant molecule (PIM) is expressed by two stages of the parasite: the sporozoite, which is...


Toye, Philip G.Musoke, A.J.Naessens, Jan[Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes]Role of the polymorphic immunodominant molecule in entry of Theileria parva sporozoites into bovine lymphocytes
Newson, J.Naessens, JanStagg, D.A.Black, S.J.[A cell surface antigen associated with Theileria parva lawrencei -infected bovine lymphoid cells]A cell surface antigen associated with Theileria parva lawrencei -infected bovine lymphoid cells

Infections caused by Mycoplasma species belonging to the ‘mycoides cluster’ negatively affect the agricultural sector through losses in livestock productivity. These Mycoplasma strains are resistant to many conventional antibiotics due to the total lack of cell wall. Therefore, there is an urgent...


Kama-Kama, F.Omosa, L.K.Ng'ang'a, J.Maina, N.Osanjo, G.Yaouba, SouaibouIlias, M.Midiwo, JacobNaessens, Jan[Antimycoplasmal Activities of Compounds from Solanum aculeastrum and Piliostigma thonningii against Strains from the Mycoplasma mycoides Cluster]Antimycoplasmal Activities of Compounds from Solanum aculeastrum and Piliostigma thonningii against Strains from the Mycoplasma mycoides Cluster
Kierstein, S.Noyes, H.A.Nakamura, Y.Naessens, JanKemp, Stephen J.Iraqi, F.A.Gibson, John P.[Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract]Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract

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