This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...
Kierstein, S.
,
Noyes, H.
,
Naessens, Jan
,
Nakamura, Y.
,
Pritchard, J.
,
Gibson, John P.
,
Kemp, Stephen J.
,
Brass, A.
,
[Gene expression profiling in a mouse model for African trypanosomiasis]
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Gene expression profiling in a mouse model for African trypanosomiasis
Synthetic antimicrobial 9-mer peptides (designated as peptides A and B) designed on the basis of insect defensins and their effects on the growth of African trypanosomes were examined using two isolates of Trypanosoma congolense, IL1180 and IL3338, and two isolates of Trypanosoma brucei brucei, I...
Kitani, H.
,
Naessens, Jan
,
Kubo, M.
,
Nakamura, Y.
,
Iraqi, F.A.
,
Gibson, John P.
,
Yamakawa, M.
,
[Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture]
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Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture
The membrane-associated form of the variable surface glycoprotein (mfVSG) from African trypanosomes is a potent macrophage activator capable of inducing production of tumor necrosis factor z (TNFalfa) in both bovine and murine models. Using a bovine model. we have re-investigated the hypothesis t...
Sileghem, M.R.
,
Saya, R.
,
Grab, D.J.
,
Naessens, Jan
,
[An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes]
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An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes
Serum Ig from Trypanosoma congolense-infected cattle were affinity-purified using immobilised trypanosome or non-trypanosome antigens (beta-galactosidase, cytochrome C and ferritin). The bound and unbound IgG and IgM fractions were collected and tested in ELISA for reactivity to each antigen. The...
Buza, J.
,
Naessens, Jan
,
[Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive]
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Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive
Although specific immunoglobulin (Ig) and B cell responses are suppressed during an infection, there is a general activation of the humoral component of the immune system in infections with African trypanosomes. The changes in the humoral immune systems during infections are summarised in this pa...
Naessens, Jan
,
[CD5+ B lymphocytes in cattle infected with African trypanosomiasis]
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CD5+ B lymphocytes in cattle infected with African trypanosomiasis
It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exp...
Williams, D.J.L.
,
Taylor, K.
,
Newson, J.
,
Gichuki, B.
,
Naessens, Jan
,
[The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance]
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The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance
Kierstein, S.
,
Noyes, H.A.
,
Nakamura, Y.
,
Naessens, Jan
,
Kemp, Stephen J.
,
Iraqi, F.A.
,
Gibson, John P.
,
[Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract]
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Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract
Nakamura, Y.
,
Tsuchiya, Y.
,
Naessens, Jan
,
Gibson, John P.
,
Iraqi, F.A.
,
[Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract]
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Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract
Alimohammadian, M.H.
,
Anderson, S.
,
Brass, A.
,
Gibson, John P.
,
Hulme, H.
,
Iraqi, F.A.
,
Kemp, Stephen J.
,
Agaba, Morris
,
Naessens, Jan
,
Noyes, H.A.
,
[Identification of gene networks associated with anaemia caused by Trypanosoma congolense]
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Identification of gene networks associated with anaemia caused by Trypanosoma congolense