Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-alpha (TNF-alpha), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia...
Naessens, Jan
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Kitani, H.
,
Nakamura, Y.
,
Yagi, Y.
,
Sekikawa, K.
,
Iraqi, F.A.
,
[TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]
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TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and ...
Naessens, Jan
,
Kitani, H.
,
Momotani, E.
,
Sekikawa, K.
,
Nthale, J.M.
,
Iraqi, F.A.
,
[Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response]
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Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response
Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...
Naessens, Jan
,
Teale, A.J.
,
Sileghem, M.R.
,
[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]
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Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
The membrane-associated form of the variable surface glycoprotein (mfVSG) from African trypanosomes is a potent macrophage activator capable of inducing production of tumor necrosis factor z (TNFalfa) in both bovine and murine models. Using a bovine model. we have re-investigated the hypothesis t...
Sileghem, M.R.
,
Saya, R.
,
Grab, D.J.
,
Naessens, Jan
,
[An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes]
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An accessory role for the diacylglycerol moiety of variable surface glycoprotein of African trypanosomes in the simulation of bovine monocytes
Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...
Kitani, H.
,
Yagi, Y.
,
Naessens, Jan
,
Sekikawa, K.
,
Iraqi, F.A.
,
[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene]
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The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene