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Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...


Behnke, J.M.Iraqi, F.A.Mugambi, J.M.M.Clifford, S.Nagda, S.M.Wakelin, D.Kemp, Stephen J.Leyden, B.Gibson, John P.[High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice]High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice

Nine hundred and thirty-six East African Zebu village calves in an area of high trypanosomiasis risk in south-western Ethiopia were monitored monthly with their dams from birth to 3 years of age. Mean packed red cell volume (PCV) and the frequency of detected parasitaemia were calculated for each...


Rowlands, G.J.Mulatu, W.Nagda, S.M.Dolan, R.B.D'Ieteren, G.D.M.[Genetic variation in packed red cell volume and frequency of parasitaemia in East African Zebu cattle exposed to drug-resistant trypanosomes]Genetic variation in packed red cell volume and frequency of parasitaemia in East African Zebu cattle exposed to drug-resistant trypanosomes

The effects of breed (Menz and Horro), season (wet and dry), and the breed by season interaction on production and response to naturally acquired gastro-intestinal (GI) nematode parasite infections (predominantly Longistrongylus elongata and Trichostrongylus spp. and a small proportion of Haemonc...


Rege, J.E.O.Tembely, S.Mukasa-Mugerwa, E.Sovani, S.Anindo, D.O.Lahlou-Kassi, A.Nagda, S.M.Baker, R.L.[Effect of breed and season on production and response to infections with gastro-intestinal nematode parasites in sheep in the highlands of Ethiopia]Effect of breed and season on production and response to infections with gastro-intestinal nematode parasites in sheep in the highlands of Ethiopia

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...


Hernández Valladares, M.Naessens, JanGibson, John P.Musoke, A.J.Nagda, S.M.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Confirmation and dissection of QTL controlling resistance to malaria in mice]Confirmation and dissection of QTL controlling resistance to malaria in mice

A genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F1 rams. This design provided an opportunity to map potentially unique genetic variation a...


Silva, M.V.B.Sonstegard, T.S.Hanotte, Olivier H.Mugambi, J.M.M.García, J.F.Nagda, S.M.Gibson, John P.Iraqi, F.A.McClintock, A.E.Kemp, Stephen J.Boettcher, P.J.Malek, M.Tassell, C.P. vanBaker, R.L.[Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep]Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep

A method is described for calculating new infection incidence from monthly field data collected between April 1994 and February 1998 from an average of 770 Ethiopian Highland Zebu cattle maintained under traditional management in the Ghibe valley, southwest Ethiopia and exposed to a high challeng...


Rowlands, G.J.Leak, S.G.A.Peregrine, A.S.Nagda, S.M.Mulatu, W.D'Ieteren, G.D.M.[The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southewest Ethiopia exposed to a high challenge with drug-resistant parasites]The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southewest Ethiopia exposed to a high challenge with drug-resistant parasites

Approximately 320 East African Zebu cows over 36 months of age were monitored monthly from 1986 to 1992 in nine village herds in an area of high trypanosomiasis risk in southwest Ethiopia where there was resistance to all available trypanocidal drugs. Cows were individually treated with diminazen...


Rowlands, G.J.Mulatu, W.Authié, E.D'Ieteren, G.D.M.Leak, S.G.A.Nagda, S.M.[Effects of trypanosomiasis on reproduction of East African Zebu cows exposed to drug-resistant trypanosomes]Effects of trypanosomiasis on reproduction of East African Zebu cows exposed to drug-resistant trypanosomes

In order to assess the effect of tsetse control on livestock productivity, 21 herds of cattle of N'Dama, Baoule and Zebu cross breeds in the region of Boundiali, northern Cote d'Ivoire, were monitored monthly for trypanosome prevalence, packed red cell volume (PCV), body weight and reproductive p...


Rowlands, G.J.D'Ieteren, G.D.M.Coulibaly, L.Hecker, P.A.Leak, S.G.A.Nagda, S.M.[Assessment of the effect of tsetse control on livestock productivity - a case study in northern Cote d'Ivoire]Assessment of the effect of tsetse control on livestock productivity - a case study in northern Cote d'Ivoire

Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J ...


Hernández Valladares, M.Naessens, JanNagda, S.M.Musoke, A.J.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi]Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi

Resistance and resilience to naturally acquired gastro-intestinal (GI) nematode parasite infections (predominantly Haemonchus contortus) were studied in 1785 lambs born over six lambings (1991 to 1996) consisting of 212 Red Maasai, 311 Dorper and 1262 crossbred (Red Maasai-Dorper) lambs in the su...


Baker, R.L.Nagda, S.M.Rodríguez Zas, S.L.Southey, B.R.Audho, James O.Aduda, Eric O.Thorpe, W.R.[Resistance and resilience to gastro-intestinal nematode parasites and relationships with productivity of Red Maasai, Dorper and Red Maasai X Dorper crossbred lambs in the sub-humid tropics]Resistance and resilience to gastro-intestinal nematode parasites and relationships with productivity of Red Maasai, Dorper and Red Maasai X Dorper crossbred lambs in the sub-humid tropics

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