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Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HS...


Nakamura, Y.Naessens, JanTakata, M.Taniguchi, T.Sekikawa, K.Gibson, John P.Iraqi, F.A.[Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection]Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection

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