Initial comparison of 2 polymorphic, immunodominant molecule (PIM) cDNA sequences from Theileria parva suggested that the PIM genes consist of conserved 5' and 3' termini flanking a central variable region. Further evidence is presented, based on sequence analysis, supporting this general structu...
Toye, Philip G.
,
Gobright, E.I.
,
Nyanjui, J.
,
Nene, Vishvanath
,
Bishop, Richard P.
,
[Structure and sequence variation of the genes encoding the polymorphic, immunodominant molecule (PlM), a candidate diagnostic antigen of Theileria parva]
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Structure and sequence variation of the genes encoding the polymorphic, immunodominant molecule (PlM), a candidate diagnostic antigen of Theileria parva
Tick-borne diseases (TBDs) are a major economic constraint to livestock production in sub-Saharan Africa. ILRI is focussing on developing a range of products, such as vaccines, diagnostics and decision support services to underpin improved control programmes against these diseases. We have develo...
Morzaria, S.P.
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Katende, J.
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Musoke, A.J.
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Nene, Vishvanath
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Skilton, Robert A.
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Bishop, Richard P.
,
[Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa]
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Development of sero-diagnostic and molecular tools for the control of important tick-borne pathogens of cattle in Africa
Peptide-major histocompatibility complex (p-MHC) class I tetramer complexes have facilitated the early detection and functional characterisation of epitope specific CD8+ cytotoxic T lymphocytes (CTL). Here, we report on the generation of seven recombinant bovine leukocyte antigens (BoLA) and reco...
Svitek, Nicholas
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Hansen, A.M.
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Steinaa, Lucilla
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Saya, R.
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Awino, Elias
,
Nielsen, Morten
,
Buus, Soren
,
Nene, Vishvanath
,
[Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle]
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Use of “one-pot, mix-and-read” peptide-MHC class I tetramers and predictive algorithms to improve detection of cytotoxic T lymphocyte responses in cattle