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Journal Article 2018-05-01

Autor: Nyagwange, James Nene, Vishvanath Mwalimu, Stephen M. Henson, Sonal P. Steinaa, Lucilla Nzau, Benjamin M. Tijhaar, Edwin Pelle, Roger

East Coast fever (ECF) caused by Theileria parva kills cattle in East, Central and Southern Africa leading to significant economic losses. Vaccination is used as a control strategy against ECF and is presently dependent on deliberate infection with live sporozoites and simultaneous treatment with...

Enlace original: https://cgspace.cgiar.org/handle/10568/92522

Investigación en Agricultura
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Nyagwange, James ,  Nene, Vishvanath ,  Mwalimu, Stephen M. ,  Henson, Sonal P. ,  Steinaa, Lucilla ,  Nzau, Benjamin M. ,  Tijhaar, Edwin ,  Pelle, Roger ,  [Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro] ,  Antibodies to in silico selected GPI-anchored Theileria parva proteins neutralize sporozoite infection in vitro
Journal Article 1998

Autor: Nene, Vishvanath Morzaria, S.P. Bishop, Richard P.

When compared with other Apicomplexan organisms. Theileria parva has an execptionally small, 10-12 Mbp. genome. There are only 4 chromosomes, each in the Mbp range, and a complete physical map, based on SfiI linking data, is available for each one. A number of genes and cDNAs have been mapped to ...

Enlace original: https://cgspace.cgiar.org/handle/10568/33061

Investigación en Agricultura
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Nene, Vishvanath ,  Morzaria, S.P. ,  Bishop, Richard P. ,  [Organisation and informational content of the Theileria parva genome] ,  Organisation and informational content of the Theileria parva genome
Journal Article 2000

Autor: Hall, R. Boulter, N.R. Brown, C.G.D. Wilkie, G. Kirvar, E. Nene, Vishvanath Musoke, A.J. Glass, E.J. Morzaria, S.P.

Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These anti...

Enlace original: https://cgspace.cgiar.org/handle/10568/33093

Investigación en Agricultura
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Hall, R. ,  Boulter, N.R. ,  Brown, C.G.D. ,  Wilkie, G. ,  Kirvar, E. ,  Nene, Vishvanath ,  Musoke, A.J. ,  Glass, E.J. ,  Morzaria, S.P. ,  [Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva] ,  Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva
Journal Article 2001

Autor: Bishop, Richard P. Geysen, D. Spooner, P.R. Skilton, Robert A. Nene, Vishvanath Dolan, T.T. Morzaria, S.P.

The 'Muguga cocktail' which is composed of three Theileria parva stocks Muguga. Kiambu 5 and Serengeti-transformed has been used extensively for live vaccination against East Coast fever in cattle in eastern, central and southern Africa. Herein we describe the molecular characterization of the T....

Enlace original: https://cgspace.cgiar.org/handle/10568/33253

Investigación en Agricultura
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Bishop, Richard P. ,  Geysen, D. ,  Spooner, P.R. ,  Skilton, Robert A. ,  Nene, Vishvanath ,  Dolan, T.T. ,  Morzaria, S.P. ,  [Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle] ,  Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle
Journal Article 2003

Autor: Bishop, Richard P. Nene, Vishvanath Staeyert, J. Rowlands, G.J. Nyanjui, J. Osaso, J. Morzaria, S.P. Musoke, A.J.

Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...

Enlace original: https://cgspace.cgiar.org/handle/10568/33215

Investigación en Agricultura
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Bishop, Richard P. ,  Nene, Vishvanath ,  Staeyert, J. ,  Rowlands, G.J. ,  Nyanjui, J. ,  Osaso, J. ,  Morzaria, S.P. ,  Musoke, A.J. ,  [Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites] ,  Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites
Journal Article 2005

Autor: Kaba, S.A. Musoke, A.J. Schaap, D. Schetters, T. Rowlands, G.J. Vermeulen, A.N. Nene, Vishvanath Vlak, J.M. Oers, M.M. van

Two novel baculovirus-derived recombinant Theileria parva p67 constructs were tested for their vaccine potential against East Coast fever. Boran calves were immunized with a his-GFP-p67 fusion protein (GFP:p67DeltaSS) or with GP64:p67C, a protein fusion between a C-terminal domain of p67 and th...

Enlace original: https://cgspace.cgiar.org/handle/10568/33217

Investigación en Agricultura
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Kaba, S.A. ,  Musoke, A.J. ,  Schaap, D. ,  Schetters, T. ,  Rowlands, G.J. ,  Vermeulen, A.N. ,  Nene, Vishvanath ,  Vlak, J.M. ,  Oers, M.M. van ,  [Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle] ,  Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle
Journal Article 2004

Autor: Kaba, S.A. Schaap, D. Roode, E.C. Nene, Vishvanath Musoke, A.J. Vlak, J.M. Oers, M.M. van

East Coast fever (ECF) in cattle is caused by the tick-borne protozoan parasite Theileria parva. The major sporozoite surface antigen of T. parva (p67) is an important candidate for inclusion in a subunit vaccine. Recently, we reported the expression and production of different parts of p67 as f...

Enlace original: https://cgspace.cgiar.org/handle/10568/33234

Investigación en Agricultura
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Kaba, S.A. ,  Schaap, D. ,  Roode, E.C. ,  Nene, Vishvanath ,  Musoke, A.J. ,  Vlak, J.M. ,  Oers, M.M. van ,  [Improved immunogenicity of novel baculovirus-derived Theileria parva p67 subunit antigens] ,  Improved immunogenicity of novel baculovirus-derived Theileria parva p67 subunit antigens
Journal Article 2005

Autor: Musoke, A.J. Rowlands, G.J. Nene, Vishvanath Nyanjui, J. Katende, J. Spooner, P.R. Mwaura, S. Odongo, D. Nkonge, C. Mbogo, S. Bishop, Richard P. Morzaria, S.P.

Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33216

Investigación en Agricultura
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Musoke, A.J. ,  Rowlands, G.J. ,  Nene, Vishvanath ,  Nyanjui, J. ,  Katende, J. ,  Spooner, P.R. ,  Mwaura, S. ,  Odongo, D. ,  Nkonge, C. ,  Mbogo, S. ,  Bishop, Richard P. ,  Morzaria, S.P. ,  [Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge] ,  Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge
Journal Article 2000

Autor: Nene, Vishvanath Bishop, Richard P. Morzaria, S.P. Gardner, M.J. Sugimoto, C. Ole-MoiYoi, O.K. Fraser, C.M. Irvin, A.

The discipline of genomics is setting new paradigms in research approaches to resolving problems in human and animal health. We propose to determine the genome sequence of Theileria parva, a pathogen of cattle, using the random shotgun approach pioneered at The Institute for Genomic Research (TIG...

Enlace original: https://cgspace.cgiar.org/handle/10568/28787

Investigación en Agricultura
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Nene, Vishvanath ,  Bishop, Richard P. ,  Morzaria, S.P. ,  Gardner, M.J. ,  Sugimoto, C. ,  Ole-MoiYoi, O.K. ,  Fraser, C.M. ,  Irvin, A. ,  [Theileria parva genomics reveals an atypical apicomplexan genome] ,  Theileria parva genomics reveals an atypical apicomplexan genome

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