The 'Muguga cocktail' which is composed of three Theileria parva stocks Muguga. Kiambu 5 and Serengeti-transformed has been used extensively for live vaccination against East Coast fever in cattle in eastern, central and southern Africa. Herein we describe the molecular characterization of the T....
Bishop, Richard P.
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Geysen, D.
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Spooner, P.R.
,
Skilton, Robert A.
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Nene, Vishvanath
,
Dolan, T.T.
,
Morzaria, S.P.
,
[Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle]
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Molecular and immunological characterisation of Theileria parva stocks which are components of the Muguga cocktail used for vaccination against East Coast fever in cattle
Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymor...
Graham, S.P.
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Saya, R.
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Awino, Elias
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Ngugi, D.
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Nyanjui, J.K.
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Hecker, R.
,
Taracha, E.L.N.
,
Nene, Vishvanath
,
[Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva]
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Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva
Theileria parva, a tick-transmitted protozoan parasite related to Plasmodium spp., causes the disease East Coast fever, an acute and usually fatal lymphoproliferative disorder of cattle in Africa. Previous studies using sera from cattle that have survived infection identified a polymorphic immuno...
Toye, Philip G.
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Metzelaar, M.J.
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Wijngaard, P.L.J.
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Nene, Vishvanath
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Iams, K.P.
,
Roose, J.
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Nyanjui, J.K.
,
Gobright, E.I.
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Musoke, A.J.
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Clevers, H.C.
,
[Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva]
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Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva
T cell responses contribute to immunity against many intracellular infections. There is, for example, strong evidence that major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs) play an essential role in mediating immunity to East Coast fever (ECF), a fatal lymph...
Nene, Vishvanath
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Svitek, Nicholas
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Toye, Philip G.
,
Golde, W.T.
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Barlow, J.
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Buus, Soren
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Nielsen, Morten
,
[Designing bovine T cell vaccines via reverse immunology]
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Designing bovine T cell vaccines via reverse immunology