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Rift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A ‘One Health’ vaccine develo...


Warimwe, G.M.Gesharisha, J.Carr, B.V.Otieno, S.Otingah, K.Wright, D.Charleston, B.Okoth, Edward A.Elena, L.G.Lorenzo, G.Ayman, E.B.Alharbi, N.K.Al-Dubaib, M.A.Brun, A.Gilbert, S.C.Nene, VishvanathHill, A.V.S.[Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever]Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever
Morzaria, S.P.Musoke, A.J.Young, J.Nene, Vishvanath[The biology of Theileria parva and its importance in the development of a novel vaccine]The biology of Theileria parva and its importance in the development of a novel vaccine

The Development of a recombinant Theileria parva vaccine is discussed under the following headings: mechanisms of protection against ECF [East Coast fever]; cloning and expression of p67; immunization and challenge of cattle; interpretation of immunization and challenge data.


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[A recombinant vaccine for Theileria parva]A recombinant vaccine for Theileria parva
Musoke, A.J.Nene, VishvanathMcKeever, Declan J.[Epitope specificity of bovine immune responses to the major surface antigen of Theileria parva sporozoites]Epitope specificity of bovine immune responses to the major surface antigen of Theileria parva sporozoites
Mwangi, D.M.Graham, S.P.Pelle, RogerHonda, Y.Tonukari, N.J.Yamage, I.M.Glew, E.J.Villiers, Etienne P. deShah, TushaarBishop, Richard P.Abuya, E.Awino, EliasGachanja, J.Luyai, A.E.Mbwika, F.Muthiani, A.M.Ndegwa, D.M.Njahira, Moses N.Nyanjui, J.K.Onono, F.O.Osaso, J.Saya, R.M.Wildmann, C.Fraser, C.M.Maudlin, I.Gardner, M.J.Morzaria, S.P.Loosmore, S.Gilbert, S.C.Audonnet, J.C.Bruggen, P. van derNene, VishvanathTaracha, E.L.N.[Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?]Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?

In this paper genomic research is discussed with regard to prospects for improving livestock productivity. Topics of discussion include, constraints to livestock productivity in developing countries; biotechnology research at ILRI; improvement of rumen fermentation; livestock genetic resources an...


Nene, VishvanathMorzaria, S.P.Baker, L.Odonyo, A.Rege, J.E.O.Zerbini, E.Bishop, Richard P.[Genomics research: Prospects for improving livestock productivity]Genomics research: Prospects for improving livestock productivity

The major sporozoite surface antigen of Theileria annulata (SPAG-1) is a candidate for inclusion in a subunit vaccine. In this paper we summarize the results of 4 vaccination experiments using recombinant SPAG-1 expressed in different systems and presented in different adjuvants. The antigen has ...


Boulter, N.Brown, D.Wilkie, G.Williamson, S.Kirvar, E.Knight, P.Glass, E.Campbell, J.Morzaria, S.P.Nene, VishvanathMusoke, A.J.Oliveria, C. deGubbels, M.J.Jongejan, F.Hall, R.[Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems]Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems

Theileria parva, a protozoan parasite of cattle, causes a disease called East Coast fever. The disease is of economic importance because it causes high morbidity and mortality and limits the development of the cattle industry. This paper highlights the experiences with immunization against Theile...


Musoke, A.J.McKeever, Declan J.Morzaria, S.P.Nkonge, C.Nene, Vishvanath[Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen]Experiences with immunization against Theileria parva using p67, a sporozoite surface antigen
Svitek, NicholasSteinaa, LucillaSaya, R.Awino, EliasNielsen, MortenBuus, SorenNene, Vishvanath[The quest for the needle (antigen) in the haystack (pathogen): Immunoinformatics to the rescue]The quest for the needle (antigen) in the haystack (pathogen): Immunoinformatics to the rescue

T cell responses contribute to immunity against many intracellular infections. There is, for example, strong evidence that major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs) play an essential role in mediating immunity to East Coast fever (ECF), a fatal lymph...


Nene, VishvanathSvitek, NicholasToye, Philip G.Golde, W.T.Barlow, J.Buus, SorenNielsen, Morten[Designing bovine T cell vaccines via reverse immunology]Designing bovine T cell vaccines via reverse immunology

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